HCSGD entry for VIP

1. General information

Official gene symbolVIP
Entrez ID7432
Gene full namevasoactive intestinal peptide
Other gene symbolsPHM27
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0005179Hormone activityIDA IEAmolecular_function
GO:0005184Neuropeptide hormone activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007589Body fluid secretionTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009966Regulation of signal transductionIEAbiological_process
GO:0010579Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0032880Regulation of protein localizationIDAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043267Negative regulation of potassium ion transportIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIDAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0060406Positive regulation of penile erectionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20636953380.82680972990.87558628301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0746726063
GSE13712_SHEARDown-0.2425258823
GSE13712_STATICDown-0.0809440554
GSE19018Down-0.0483767864
GSE19899_A1Up0.2127144645
GSE19899_A2Up0.2705716134
PubMed_21979375_A1Up0.3229697820
PubMed_21979375_A2Down-0.3543123124
GSE35957Up0.1869465060
GSE36640Down-0.0436323403
GSE54402Up0.3801834652
GSE9593Up0.2404580030
GSE43922Up0.0448524401
GSE24585Up0.4475614492
GSE37065Up0.0485707000
GSE28863_A1Up0.0193751821
GSE28863_A2Down-0.0943772637
GSE28863_A3Up0.1143902910
GSE28863_A4Up0.0328526596
GSE48662Down-0.1020270804

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016951MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

3018700VIP regulation of a human pancreatic cancer cell line: Capan-1
3018700VIP and secretin control the secretory function of the normal pancreas
30187009 X 10(-9) M for VIP; 2 +/- 0
3018700VIP elicited a cAMP rise, the half maximal response being obtained at 1
3018700VIP receptors were found to be modulated by two factors: cell ageing and cell density
3018700Cells chronically treated with VIP showed a slight decrease of their proliferation; insulin exerted an opposite effect
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