HCSGD entry for VEGFA

1. General information

Official gene symbol	VEGFA
Entrez ID	7422
Gene full name	vascular endothelial growth factor A
Other gene symbols	MVCD1 VEGF VPF
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	IDA	biological_process
GO:0001525	Angiogenesis	IDA	biological_process
GO:0001541	Ovarian follicle development	IEA ISS	biological_process
GO:0001569	Patterning of blood vessels	IEA ISS	biological_process
GO:0001570	Vasculogenesis	TAS	biological_process
GO:0001666	Response to hypoxia	IDA IEA	biological_process
GO:0001701	In utero embryonic development	IEA ISS	biological_process
GO:0001822	Kidney development	IEA ISS	biological_process
GO:0001934	Positive regulation of protein phosphorylation	IDA	biological_process
GO:0001938	Positive regulation of endothelial cell proliferation	IDA ISS	biological_process
GO:0001968	Fibronectin binding	IDA	molecular_function
GO:0001974	Blood vessel remodeling	IEA	biological_process
GO:0002042	Cell migration involved in sprouting angiogenesis	IDA	biological_process
GO:0002052	Positive regulation of neuroblast proliferation	IEA ISS	biological_process
GO:0002053	Positive regulation of mesenchymal cell proliferation	IEA ISS	biological_process
GO:0002092	Positive regulation of receptor internalization	IDA	biological_process
GO:0002575	Basophil chemotaxis	IDA	biological_process
GO:0002576	Platelet degranulation	TAS	biological_process
GO:0002687	Positive regulation of leukocyte migration	TAS	biological_process
GO:0003007	Heart morphogenesis	ISS	biological_process
GO:0003151	Outflow tract morphogenesis	IEA ISS	biological_process
GO:0003169	Coronary vein morphogenesis	IEA ISS	biological_process
GO:0005125	Cytokine activity	IDA ISS	molecular_function
GO:0005161	Platelet-derived growth factor receptor binding	IPI	molecular_function
GO:0005172	Vascular endothelial growth factor receptor binding	IPI	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005576	Extracellular region	TAS	cellular_component
GO:0005578	Proteinaceous extracellular matrix	NAS	cellular_component
GO:0005604	Basement membrane	IEA	cellular_component
GO:0005615	Extracellular space	IDA IEA ISS	cellular_component
GO:0005737	Cytoplasm	IDA IEA	cellular_component
GO:0006357	Regulation of transcription from RNA polymerase II promoter	IMP	biological_process
GO:0007399	Nervous system development	TAS	biological_process
GO:0007498	Mesoderm development	IEA ISS	biological_process
GO:0007595	Lactation	IEA ISS	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0008083	Growth factor activity	IDA IEA ISS	molecular_function
GO:0008201	Heparin binding	IDA IEA IMP	molecular_function
GO:0008283	Cell proliferation	IEA	biological_process
GO:0008284	Positive regulation of cell proliferation	IDA	biological_process
GO:0008360	Regulation of cell shape	IDA	biological_process
GO:0009409	Response to cold	IEA	biological_process
GO:0009986	Cell surface	IDA	cellular_component
GO:0010469	Regulation of receptor activity	IPI	biological_process
GO:0010595	Positive regulation of endothelial cell migration	IDA	biological_process
GO:0010628	Positive regulation of gene expression	IDA	biological_process
GO:0016020	Membrane	IEA	cellular_component
GO:0030141	Secretory granule	IDA	cellular_component
GO:0030168	Platelet activation	TAS	biological_process
GO:0030212	Hyaluronan metabolic process	IEA	biological_process
GO:0030224	Monocyte differentiation	IDA	biological_process
GO:0030225	Macrophage differentiation	IDA	biological_process
GO:0030324	Lung development	ISS	biological_process
GO:0030335	Positive regulation of cell migration	IDA	biological_process
GO:0030855	Epithelial cell differentiation	IEA ISS	biological_process
GO:0030949	Positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA	biological_process
GO:0031077	Post-embryonic camera-type eye development	IEA ISS	biological_process
GO:0031093	Platelet alpha granule lumen	TAS	cellular_component
GO:0031334	Positive regulation of protein complex assembly	IDA	biological_process
GO:0031954	Positive regulation of protein autophosphorylation	IDA	biological_process
GO:0031988	Membrane-bounded vesicle	IEA	cellular_component
GO:0032147	Activation of protein kinase activity	IDA	biological_process
GO:0032793	Positive regulation of CREB transcription factor activity	IDA	biological_process
GO:0033138	Positive regulation of peptidyl-serine phosphorylation	IDA	biological_process
GO:0035148	Tube formation	IDA	biological_process
GO:0035767	Endothelial cell chemotaxis	IDA	biological_process
GO:0035924	Cellular response to vascular endothelial growth factor stimulus	IDA	biological_process
GO:0036303	Lymph vessel morphogenesis	IEA ISS	biological_process
GO:0038033	Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	IDA	biological_process
GO:0038084	Vascular endothelial growth factor signaling pathway	IEA	biological_process
GO:0038091	Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	IDA	biological_process
GO:0038190	VEGF-activated neuropilin signaling pathway	ISS	biological_process
GO:0040007	Growth	IEA ISS	biological_process
GO:0042056	Chemoattractant activity	IDA	molecular_function
GO:0042088	T-helper 1 type immune response	IEA	biological_process
GO:0042462	Eye photoreceptor cell development	IEA ISS	biological_process
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0042803	Protein homodimerization activity	IEA ISS	molecular_function
GO:0043066	Negative regulation of apoptotic process	IMP	biological_process
GO:0043117	Positive regulation of vascular permeability	IDA IEA	biological_process
GO:0043129	Surfactant homeostasis	IEA ISS	biological_process
GO:0043154	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological_process
GO:0043183	Vascular endothelial growth factor receptor 1 binding	IPI	molecular_function
GO:0043184	Vascular endothelial growth factor receptor 2 binding	IPI	molecular_function
GO:0043406	Positive regulation of MAP kinase activity	IDA	biological_process
GO:0043524	Negative regulation of neuron apoptotic process	IEA	biological_process
GO:0043536	Positive regulation of blood vessel endothelial cell migration	IDA	biological_process
GO:0045766	Positive regulation of angiogenesis	IDA IEA IMP	biological_process
GO:0045779	Negative regulation of bone resorption	IEA	biological_process
GO:0045785	Positive regulation of cell adhesion	IDA	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	IDA IEA IMP	biological_process
GO:0046982	Protein heterodimerization activity	IDA	molecular_function
GO:0048010	Vascular endothelial growth factor receptor signaling pathway	IDA IEA TAS	biological_process
GO:0048018	Receptor agonist activity	IPI	molecular_function
GO:0048255	MRNA stabilization	IEA	biological_process
GO:0048286	Lung alveolus development	IEA	biological_process
GO:0048469	Cell maturation	IEA ISS	biological_process
GO:0048593	Camera-type eye morphogenesis	IEA ISS	biological_process
GO:0048661	Positive regulation of smooth muscle cell proliferation	IEA	biological_process
GO:0048739	Cardiac muscle fiber development	IEA ISS	biological_process
GO:0048754	Branching morphogenesis of an epithelial tube	ISS	biological_process
GO:0048842	Positive regulation of axon extension involved in axon guidance	IEA ISS	biological_process
GO:0048844	Artery morphogenesis	ISS	biological_process
GO:0050679	Positive regulation of epithelial cell proliferation	IEA ISS	biological_process
GO:0050731	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological_process
GO:0050840	Extracellular matrix binding	IC	molecular_function
GO:0050918	Positive chemotaxis	IDA IEA	biological_process
GO:0050927	Positive regulation of positive chemotaxis	IDA	biological_process
GO:0050930	Induction of positive chemotaxis	IDA NAS	biological_process
GO:0051272	Positive regulation of cellular component movement	IDA	biological_process
GO:0051781	Positive regulation of cell division	IEA	biological_process
GO:0051894	Positive regulation of focal adhesion assembly	IDA	biological_process
GO:0051897	Positive regulation of protein kinase B signaling	IEA	biological_process
GO:0060319	Primitive erythrocyte differentiation	IEA ISS	biological_process
GO:0060326	Cell chemotaxis	IEA	biological_process
GO:0060749	Mammary gland alveolus development	IEA ISS	biological_process
GO:0060754	Positive regulation of mast cell chemotaxis	IDA	biological_process
GO:0060948	Cardiac vascular smooth muscle cell development	IEA ISS	biological_process
GO:0060982	Coronary artery morphogenesis	IEA ISS	biological_process
GO:0061418	Regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS	biological_process
GO:0061419	Positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IMP	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IEA	biological_process
GO:0071456	Cellular response to hypoxia	IDA TAS	biological_process
GO:0071542	Dopaminergic neuron differentiation	IEA ISS	biological_process
GO:0071679	Commissural neuron axon guidance	IEA ISS	biological_process
GO:0090037	Positive regulation of protein kinase C signaling	IDA	biological_process
GO:0090050	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	biological_process
GO:0090190	Positive regulation of branching involved in ureteric bud morphogenesis	IEA ISS	biological_process
GO:0090259	Regulation of retinal ganglion cell axon guidance	ISS	biological_process
GO:1900086	Positive regulation of peptidyl-tyrosine autophosphorylation	IDA	biological_process
GO:1900745	Positive regulation of p38MAPK cascade	IDA	biological_process
GO:1901492	Positive regulation of lymphangiogenesis	IEA	biological_process
GO:1901727	Positive regulation of histone deacetylase activity	IDA	biological_process
GO:1902336	Positive regulation of retinal ganglion cell axon guidance	IEA ISS	biological_process
GO:1902533	Positive regulation of intracellular signal transduction	IDA	biological_process
GO:2000273	Positive regulation of receptor activity	IPI	biological_process
GO:2001237	Negative regulation of extrinsic apoptotic signaling pathway	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0057335891	0.2935620265	0.1985117647	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.8309789501
GSE13712_SHEAR	Down	-0.4877322310
GSE13712_STATIC	Up	0.1426021948
GSE19018	Up	0.2493757587
GSE19899_A1	Up	0.4527131272
GSE19899_A2	Up	1.8415313513
PubMed_21979375_A1	Up	1.8105154772
PubMed_21979375_A2	Up	0.7810819713
GSE35957	Down	-1.2000703813
GSE36640	Down	-1.4500966794
GSE54402	Down	-0.1305501631
GSE9593	Up	0.4922266102
GSE43922	Up	1.1591433820
GSE24585	Up	0.0452844200
GSE37065	Up	0.1225939009
GSE28863_A1	Up	0.7354217700
GSE28863_A2	Up	1.1178683229
GSE28863_A3	Up	0.0268011753
GSE28863_A4	Down	-0.3731714982
GSE48662	Up	0.6758711292

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Compound	Target	Confidence score	Uniprot
CHEMBL265885	CHEMBL1783	4	P15692
CHEMBL382044	CHEMBL1783	4	P15692
CHEMBL198643	CHEMBL1783	4	P15692

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Drugs

Name	Drug	Accession number
Bevacizumab	DB00112	BTD00087 \| BIOD00087
Minocycline	DB01017	APRD00547
Gliclazide	DB01120	APRD00460
Carvedilol	DB01136	APRD00091
Ranibizumab	DB01270	-
Pyroglutamic Acid	DB03088	EXPT00247
Tris	DB03754	EXPT03072
ABT-510	DB05434	-
VEGF-AS	DB05890	-
Aflibercept	DB08885	-

MicroRNAs

mirTarBase

MiRNA_name	mirBase ID	miRTarBase ID	Experiment	Support type	References (Pubmed ID)
hsa-miR-200b-3p	MIMAT0000318	MIRT006440	Luciferase reporter assay//Western blot	Functional MTI	21544626
hsa-miR-373-3p	MIMAT0000726	MIRT000721	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-302d-3p	MIMAT0000718	MIRT000722	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-145-5p	MIMAT0000437	MIRT006215	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22472569
hsa-miR-126-3p	MIMAT0000445	MIRT003428	Luciferase reporter assay//Reporter assay	Functional MTI	19223090
hsa-miR-126-3p	MIMAT0000445	MIRT003428	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22510476
hsa-miR-126-3p	MIMAT0000445	MIRT003428	Reporter assay;Western blot	Functional MTI	21249429
hsa-miR-147a	MIMAT0000251	MIRT003810	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-134-5p	MIMAT0000447	MIRT003811	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-140-5p	MIMAT0000431	MIRT003812	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-29b-3p	MIMAT0000100	MIRT003813	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-107	MIMAT0000104	MIRT003814	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-16-5p	MIMAT0000069	MIRT003890	Luciferase reporter assay//Reporter assay	Non-Functional MTI	15131085
hsa-miR-16-5p	MIMAT0000069	MIRT003890	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-16-5p	MIMAT0000069	MIRT003890	Luciferase reporter assay//Western blot	Functional MTI	19144909
hsa-miR-16-5p	MIMAT0000069	MIRT003890	Luciferase reporter assay	Functional MTI	23083510
hsa-miR-16-5p	MIMAT0000069	MIRT003890	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23104180
hsa-miR-16-5p	MIMAT0000069	MIRT003890	Luciferase reporter assay	Functional MTI	23233752
hsa-miR-93-5p	MIMAT0000093	MIRT004055	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-17-5p	MIMAT0000070	MIRT004271	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-150-5p	MIMAT0000451	MIRT004272	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-195-5p	MIMAT0000461	MIRT004273	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-15b-5p	MIMAT0000417	MIRT004274	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-15a-5p	MIMAT0000068	MIRT004275	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-15a-5p	MIMAT0000068	MIRT004275	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23104180
hsa-miR-15a-5p	MIMAT0000068	MIRT004275	Luciferase reporter assay	Functional MTI	23233752
hsa-miR-520g-3p	MIMAT0002858	MIRT004276	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-378a-3p	MIMAT0000732	MIRT004277	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-330-3p	MIMAT0000751	MIRT004278	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-383-5p	MIMAT0000738	MIRT004443	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-125a-5p	MIMAT0000443	MIRT004445	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-361-5p	MIMAT0000703	MIRT004447	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-20a-5p	MIMAT0000075	MIRT004450	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-20b-5p	MIMAT0001413	MIRT004451	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-504-5p	MIMAT0002875	MIRT004457	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-520h	MIMAT0002867	MIRT004458	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-372-3p	MIMAT0000724	MIRT004461	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-106a-5p	MIMAT0000103	MIRT004465	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-106b-5p	MIMAT0000680	MIRT004466	ELISA//Luciferase reporter assay	Functional MTI	18320040
hsa-miR-106b-5p	MIMAT0000680	MIRT004466	Microarray	Functional MTI (Weak)	17242205
hsa-miR-34a-5p	MIMAT0000255	MIRT004513	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-205-5p	MIMAT0000266	MIRT004518	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-205-5p	MIMAT0000266	MIRT004518	Luciferase reporter assay//Reporter assay	Functional MTI	19238171
hsa-miR-34b-3p	MIMAT0004676	MIRT004519	ELISA//Luciferase reporter assay	Non-Functional MTI	18320040
hsa-miR-200c-3p	MIMAT0000617	MIRT006771	Luciferase reporter assay//Western blot	Functional MTI	22569286
hsa-miR-503-5p	MIMAT0002874	MIRT007224	Luciferase reporter assay	Functional MTI	23352645
hsa-miR-335-5p	MIMAT0000765	MIRT016911	Microarray	Functional MTI (Weak)	18185580
hsa-miR-29c-3p	MIMAT0000681	MIRT020389	Sequencing	Functional MTI (Weak)	20371350
hsa-miR-9-5p	MIMAT0000441	MIRT021401	qRT-PCR;Other	Non-Functional MTI (Weak)	20173740
hsa-miR-133a-3p	MIMAT0000427	MIRT021711	Reporter assay	Non-Functional MTI	21249429
hsa-miR-101-3p	MIMAT0000099	MIRT027248	Sequencing	Functional MTI (Weak)	20371350
hsa-miR-21-5p	MIMAT0000076	MIRT030717	qRT-PCR	Functional MTI (Weak)	19435867
hsa-miR-21-5p	MIMAT0000076	MIRT030717	Western blot;qRT-PCR	Functional MTI	21544242

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mirRecord

MicroRNA name	mirBase ID	Target site number	MiRNA mature ID	Test method inter	MiRNA regulation site	Pubmed ID
hsa-miR-34a-5p	MIMAT0000255	1	hsa-miR-34a	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-140-5p	MIMAT0000431	NA	hsa-miR-140-5p	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-15a-5p	MIMAT0000068	1	hsa-miR-15a	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-16-5p	MIMAT0000069	NA	hsa-miR-16	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-147a	MIMAT0000251	NA	hsa-miR-147	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-520h	MIMAT0002867	1	hsa-miR-520h	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-205-5p	MIMAT0000266	1	hsa-miR-205	{ELISA}	{overexpression by siRNA transfection}	18320040
hsa-miR-126-3p	MIMAT0000445	1	hsa-miR-126			19223090
hsa-miR-205-5p	MIMAT0000266	1	hsa-miR-205			19238171
hsa-miR-126-3p	MIMAT0000445	NA	hsa-miR-126	{Western blot}	{endogenous}	21249429
hsa-miR-16-5p	MIMAT0000069	1	hsa-miR-16	{Western blot}	{overexpression by miRNA mimics tranfection}	21885851
hsa-miR-424-5p	MIMAT0001341	NA	hsa-miR-424	{Western blot}	{overexpression by miRNA mimics tranfection}	21885851

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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 43 abstracts the gene occurs.

PubMed ID of the article	Sentenece the gene occurs
27917303	Then, the effect of synthetic miR-146a mimetic on IL-6 and VEGF-A expression was analyzed in RPE cells treated with and without TNF-alpha
27917303	Overexpression of miR-146a by miRNA mimics inhibited VEGF-A and TNF-alpha-induced IL-6 expression
27508009	Furthermore, we confirmed that the expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and phosphoryl-Akt were augmented in SRT1720-treated senescent HUVECs
27009837	Bmi-1 knockdown by Ad-Bmi-1i downregulated VEGF via inhibiting AKT activity
26654980	Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
26654980	Most important, we show for the first time that senescent ARPE-19 cells upregulated vascular endothelial growth factor (VEGF) and simultaneously downregulated complement factor H (CFH) expression
26433963	In this report we show that senescent human peritoneal mesothelial cells (HPMCs) alter the secretory profile of ovarian cancer cells (A2780, OVCAR-3, SKOV-3) by increasing the release of four angiogenic agents: CXCL1, CXCL8, HGF, and VEGF
26420897	Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature
26105007	Upon LPS treatment, SV cells also developed senescence-associated secretory phenotype (SASP), as demonstrated by the increased expression of TNFalpha, IL-1beta, IL-6, MCP-1, and VEGFalpha
26005508	Initial animal studies and phase I clinical trials with vascular endothelial growth factor (VEGF) or fibroblast growth factor (FGF) demonstrated promising results, inspiring scientists to progress forward
25952632	Under these conditions, the anti-senescence genes TERT, bFGF, VEGF, and ANG were increased, whereas the senescence-related genes ATM, p21, and p53 were decreased
25797700	We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC)
25633211	Pre-clinical studies and Phase I clinical trials using VEGF and fibroblast growth factor (FGF) demonstrated promising results; however, more rigorous Phase II and III clinical trials failed to demonstrate benefits for CLI patients
25633211	EXPERT OPINION: Compared with VEGF and FGF, HGF has a unique molecular effect on inflammation, fibrosis and cell senescence under pathological conditions
25453983	After 2 weeks, the cells were treated with either VEGF or its vehicle and their transepithelial electrical resistance (TEER) was measured
25453983	RESULTS: VEGF was significantly more effective in reducing the TEER of the high PDL ARPE-19 cell layers than the low PDL layers (25% decrease vs
25453983	CONCLUSIONS: The present results show that the ability of VEGF to reduce the barrier function of RPE cell layers is greater in high PDL layers, which display signs of senescence, than in low PDL layers
25388834	Our data showed that both eNOS and Akt phosphorylation, VEGF expression and nitric oxide production were significantly decreased, RMVECs ageing and apoptosis increased after ox-LDL induction for 24 hrs, all of which were effectively reversed by ciglitazone pre-treatment
25192254	The expression of VEGF and VEGFR2 was reduced in Sirt3KO-EPCs
25192254	In post-MI mice, BMC treatment increased number of Sca1+/c-kit+ cells; enhanced VEGF expression and angiogenesis whereas Sirt3KO-BMC treatment had little effects
25158160	Hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) are all potent angiogenic growth factors in animal models of ischemia, but their therapeutic effects are not the same in animal experiments and clinical trials
25158160	A multicenter, double-blind, placebo-controlled phase III clinical trial in Japan and a US phase II clinical trial of HGF gene therapy for critical limb ischemia (CLI) demonstrated a significant improvement in primary end points and an increase in transcutaneous partial pressure of oxygen even after one year compared with placebo, whereas effectiveness of VEGF and FGF treatment for CLI has not yet been shown
25158160	Moreover, our recent publication and another researcher demonstrated that HGF acts as an anti-inflammatory cytokine, while VEGF and FGF act as pro-inflammatory cytokine
25108204	That is, DHA supplement inhibited cellular proliferation, destroyed cell membrane integrity, enhanced cellular senescence, increased vascular endothelial growth factor (VEGF) release, and decreased phagocytic function
24681605	Expression of two senescence-associated cytokines (VEGFA and MCP1) was durably increased by adjuvant chemotherapy
23770676	Coupling quantitative proteomics with small-molecule screens, we identified multiple SASP components mediating paracrine senescence, including TGF-beta family ligands, VEGF, CCL2 and CCL20
23758730	In addition, angiogenesis and VEGF expression in CT26 colon carcinoma was significantly inhibited by TLBZT treatment
23583398	7-fold) and down-regulated expression of vascular endothelial growth factor-A (0
23503666	The downregulation of vascular endothelial growth factor (VEGF) was observed in the irradiated HUVECs as the PN increased
23174937	Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2
23174937	VEGF polymorphisms were the most common and detected at four loci
22904099	Compared with young EC, senescent cells displayed increased expression of senescence-associated beta-galactosidase, nitric oxide synthase (eNOS), and AKT kinase, and secreted increased amounts of growth factors (VEGF, TGF-beta), cytokines (IL-6, IL-8, MCP-1), adhesion molecules (sICAM-1), and matrix proteins (fibronectin)
22797809	Atm deficiency also lowered tumor angiogenesis and enhanced the antiangiogenic action of vascular endothelial growth factor (Vegf) blockade
22470345	Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program
22340562	Expression of OPN, hypoxia inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) proteins was analyzed by Western blotting analysis
22340562	RESULTS: HIF-1 and VEGF proteins in MDA-MB-343 cells were significantly downregulated upon the efficient knockdown of OPN expression under either hypoxia or normoxia environment
21793037	The level of plasma vascular endothelial growth factor (VEGF) was measured by ELISA
21793037	In addition, there were higher levels of plasma VEGF in CA patients compared with healthy control subjects
21622994	RESULTS: Uremic MSCs showed decreased expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and stromal cell-derived factor (SDF)-1alpha, increased cellular senescence, decreased proliferation, defects in migration in response to VEGF and SDF-1alpha and in vitro tube formation
21622994	Uremia decreased hypoxia-inducible factor-1alpha, VEGF and VEGFR1 expression under hypoxia and Akt phosphorylation in both basal and VEGF-stimulated states
21618508	Vascular endothelial growth factor (VEGF) inhibitors, such as bevacizumab, have improved outcomes in metastatic colorectal cancer (CRC)
21618508	Recent studies have suggested that VEGF can delay the onset of cellular senescence in human endothelial cells
21618508	As VEGF receptors are known to be upregulated in CRC, we hypothesized that VEGF inhibition may directly influence cellular senescence in this disease
21618508	To understand how VEGF inhibitors may regulate cellular senescence, we noted that among the two important regulators of senescent growth arrest of tumor cells, bevacizumab-associated increase in cellular senescence coincided with an upregulation of p16 but appeared to be independent of p53
21618508	These findings demonstrate a novel antitumor activity of VEGF inhibitors in CRC, involving p16
21245959	This study investigated the effects of short- and long-term in vitro inhibition of vascular endothelial growth factor (VEGF) Receptor-2 (VEGFR-2) signaling by SU5416 and other inhibitors of the VEGF signaling pathway in OECs
21245959	Migration in vitro to VEGF and stromal cell-derived factor 1 of OECs was assessed
21245959	Naturally senescent cells and cells rendered senescent by VEGFR-2 TKIs had reduced VEGFR-2 and CXCR-4 expression and demonstrated reduced migratory ability to VEGF
20713685	Exposure to VAT adipocytes caused more EC senescence-associated beta-galactosidase activity than SAT adipocytes, an effect reduced in the presence of vascular endothelial growth factor A (VEGFA) neutralizing antibodies
20374652	Expression of the master cell cycle regulators p53 and p21 and growth factors HGF and VEGF also declined significantly at 26 months
19047582	Although both hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) are potent angiogenic growth factors in animal models of ischemia, their characteristics are not the same in animal experiments and clinical trials
19047582	To elucidate the discrepancy between HGF and VEGF, we compared the effects of HGF and VEGF on endothelial progenitor cells under angiotensin II stimulation, which is a well-known risk factor for atherosclerosis
19047582	Here, we demonstrated that HGF, but not VEGF, attenuated angiotensin II-induced senescence of endothelial progenitor cells through a reduction of oxidative stress by inhibition of the phosphatidylinositol-3,4,5-triphosphate/rac1 pathway
19047582	Potent induction of neovascularization of endothelial progenitor cells by HGF, but not VEGF, under angiotensin II was also confirmed by in vivo experiments using several models, including HGF transgenic mice
19011671	EC exhibited higher expression levels of markers of oxidative stress (lipid peroxydation level and caveolin-1 mRNA), inflammation (angiopoietin-like 2 mRNA), hypoxia (vascular endothelial growth factor (VEGF)-A mRNA), and cell damage (p53 mRNA)
18583712	Vascular endothelial growth factor (VEGF) binds both VEGF receptor-1 (VEGFR-1) and VEGF receptor-2 (VEGFR-2)
18583712	Activation of VEGFR-2 is thought to play a major role in the regulation of endothelial function by VEGF
18583712	In this study, we showed that VEGFR-1 performs "fine tuning" of VEGF signaling to induce neovascularization
18583712	When VEGFR-1 expression was blocked, VEGF constitutively activated Akt signals and thus induced endothelial cell senescence via a p53-dependent pathway
18583712	These results suggest that VEGFR-1 plays a critical role in the maintenance of endothelial integrity by modulating the VEGF/Akt signaling pathway
17402563	VEGF has been recognized as a predominant factor to induce the ischemic retinal neovascularization
17402563	We found that retinal vascular cells have a characteristic pattern in VEGF receptor expression, which causes vascular pathology more frequently in the retina than in other organs
17402563	Finally, we found that erythropoietin is an ischemia-induced angiogenic factor that acts independently and as potently as VEGF in proliferative diabetic retinopathy (PDR)
17402563	Our study utilizing human vitreous samples demonstrates that the VEGF level is particularly high and strongly associated with angiogenic activity in PDR patients
17402563	The potential of VEGF inhibitors has recently been recognized in clinical applications
16880208	Accordingly, increased vascular endothelial growth factor (VEGF) expression was a frequent characteristic of senescent human and mouse fibroblasts in culture
16880208	Increased VEGF expression was specific to the senescent phenotype and increased whether senescence was induced by replicative exhaustion, overexpression of p16(Ink4a), or overexpression of oncogenic RAS
16880208	The senescence-dependent increase in VEGF production was accompanied by very little increase in hypoxic-inducible (transcription) factor 1 alpha protein levels, and hypoxia further induced VEGF in senescent cells
16880208	This result suggests the rise in VEGF expression at senescence is not a hypoxic response
16827160	In the immortalized HDFs, the transcriptional activity of HIF-1alpha was also evident by the accumulation of its main downstream gene targets, namely erythropoietin (EPO) and the vascular endothelial growth factor (VEGF)
16755088	Angiogenic growth factors secreted by EPCs, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), hepatocyte growth factor (HGF), and macrophage chemoattractant protein (MCP-1) from the culture medium were also measured by enzyme-linked immunosorbent assay
16755088	There was no significant difference of angiogenic growth factors (VEGF, HGF, b-FGF, and MCP-1) secreted by EPCs between the two groups
16093915	In addition, EPCs released vascular endothelial growth factor (VEGF) protein--an effect that was significantly augmented by 17beta-estradiol
16093915	Finally, in a Matrigel assay, EPCs treated with both 17beta-estradiol and VEGF were shown to be more likely to integrate into the network formation than those treated with VEGF alone
16010436	HUV-ST cells are capable of organizing into tubule-like networks with branching morphology in response to appropriate stimuli and migrate upon exposure to VEGF
12959928	Senescent BMP4-treated cells had lower ERK activation, VEGF expression, and Bcl2 expression than wild-type cells, consistent with a less proliferative, less angiogenic phenotype with increased susceptibility to death by apoptosis
12676798	In this study, we examined the relationship between telomerase activity and endothelial cell proliferation as well as the regulation of this enzyme by fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor-A (VEGF)
12676798	Treatment of quiescent HUVECs with FGF-2 restored telomerase activity in a time- and dose-dependent manner, whereas VEGF had no such effect, although both factors induced comparable mitogenic responses
12676798	CONCLUSIONS: FGF-2, but not VEGF, restores telomerase activity and maintains the replicative capacity of endothelial cells

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1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for VEGFA

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Compound

Target

Confidence score

Uniprot

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 43 abstracts the gene occurs.

PubMed ID of the article

Sentenece the gene occurs

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Individual experiment result
( "-" represent NA in the specific microarray platform )