HCSGD entry for VARS
1. General information
| Official gene symbol | VARS |
|---|---|
| Entrez ID | 7407 |
| Gene full name | valyl-tRNA synthetase |
| Other gene symbols | G7A VARS1 VARS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0004832 | Valine-tRNA ligase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006438 | Valyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2689429505 | 0.0868366475 | 0.9658581697 | 0.5591470286 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0989186369 |
| GSE13712_SHEAR | Up | 0.2365011939 |
| GSE13712_STATIC | Up | 0.2356504332 |
| GSE19018 | Up | 0.1676733077 |
| GSE19899_A1 | Down | -0.3393185278 |
| GSE19899_A2 | Down | -0.0106457321 |
| PubMed_21979375_A1 | Up | 0.4681566766 |
| PubMed_21979375_A2 | Up | 0.5148394085 |
| GSE35957 | Down | -0.4219766749 |
| GSE36640 | Down | -0.3101019927 |
| GSE54402 | Up | 0.2152632897 |
| GSE9593 | Down | -0.0687067662 |
| GSE43922 | Down | -0.0000395305 |
| GSE24585 | Down | -0.9144512032 |
| GSE37065 | Down | -0.5087185342 |
| GSE28863_A1 | Up | 0.3595952158 |
| GSE28863_A2 | Up | 0.5071218297 |
| GSE28863_A3 | Down | -0.0355854236 |
| GSE28863_A4 | Down | -0.3057475448 |
| GSE48662 | Down | -0.2672648041 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Valine | DB00161 | NUTR00060 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-760 | MIMAT0004957 | MIRT036708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038431 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038839 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040390 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042341 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042929 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043548 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049193 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051480 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
