HCSGD entry for UQCRFS1
1. General information
| Official gene symbol | UQCRFS1 |
|---|---|
| Entrez ID | 7386 |
| Gene full name | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
| Other gene symbols | RIP1 RIS1 RISP UQCR5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005750 | Mitochondrial respiratory chain complex III | IEA | cellular_component |
| GO:0008121 | Ubiquinol-cytochrome-c reductase activity | IEA | molecular_function |
| GO:0009725 | Response to hormone | IEA | biological_process |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5551613541 | 0.4169291174 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3599074522 |
| GSE13712_SHEAR | Down | -0.0603632561 |
| GSE13712_STATIC | Up | 0.0921922730 |
| GSE19018 | Down | -0.1879756084 |
| GSE19899_A1 | Down | -0.1315279500 |
| GSE19899_A2 | Up | 0.1398910579 |
| PubMed_21979375_A1 | Up | 0.6813513803 |
| PubMed_21979375_A2 | Down | -0.0387402242 |
| GSE35957 | Down | -0.1969530266 |
| GSE36640 | Down | -0.1906521631 |
| GSE54402 | Up | 0.2935879413 |
| GSE9593 | Down | -0.3538293661 |
| GSE43922 | Up | 0.0834538677 |
| GSE24585 | Down | -0.2432410380 |
| GSE37065 | Up | 0.0093138740 |
| GSE28863_A1 | Up | 0.1350119345 |
| GSE28863_A2 | Down | -0.2041497380 |
| GSE28863_A3 | Down | -0.3220143077 |
| GSE28863_A4 | Up | 0.1837703196 |
| GSE48662 | Down | -0.1132780234 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | DB04141 | EXPT00697 |
| 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole | DB04799 | - |
| METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE | DB07401 | - |
| 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE | DB07636 | - |
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | DB07763 | - |
| FAMOXADONE | DB07778 | - |
| METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE | DB08330 | - |
| 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE | DB08453 | - |
| UBIQUINONE-2 | DB08690 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT006517 | Luciferase reporter assay//Western blot | Functional MTI | 20550618 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039761 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044309 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050913 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1) |
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