HCSGD entry for UCP2
1. General information
| Official gene symbol | UCP2 |
|---|---|
| Entrez ID | 7351 |
| Gene full name | uncoupling protein 2 (mitochondrial, proton carrier) |
| Other gene symbols | BMIQ4 SLC25A8 UCPH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000303 | Response to superoxide | IEA | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0006810 | Transport | IEA NAS | biological_process |
| GO:0006839 | Mitochondrial transport | IEA | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0010942 | Positive regulation of cell death | IEA | biological_process |
| GO:0015992 | Proton transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0032869 | Cellular response to insulin stimulus | IEA | biological_process |
| GO:0034198 | Cellular response to amino acid starvation | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0061179 | Negative regulation of insulin secretion involved in cellular response to glucose stimulus | IEA | biological_process |
| GO:0070542 | Response to fatty acid | IEA | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IEA | biological_process |
| GO:0097421 | Liver regeneration | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9615364082 | 0.0007953497 | 0.9999902473 | 0.0529984810 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7406885192 |
| GSE13712_SHEAR | Down | -3.7814092842 |
| GSE13712_STATIC | Down | -1.9683348341 |
| GSE19018 | Up | 0.4255089646 |
| GSE19899_A1 | Down | -0.9445474551 |
| GSE19899_A2 | Down | -0.2666816555 |
| PubMed_21979375_A1 | Down | -0.8577582294 |
| PubMed_21979375_A2 | Down | -1.5050270998 |
| GSE35957 | Down | -0.8031823394 |
| GSE36640 | Down | -1.3194840051 |
| GSE54402 | Down | -0.6713944792 |
| GSE9593 | Down | -0.1668317063 |
| GSE43922 | Down | -0.6402512830 |
| GSE24585 | Up | 0.4703712743 |
| GSE37065 | Up | 0.2426516395 |
| GSE28863_A1 | Down | -0.4419289290 |
| GSE28863_A2 | Down | -0.6300567500 |
| GSE28863_A3 | Up | 0.1194886401 |
| GSE28863_A4 | Up | 0.2220473617 |
| GSE48662 | Down | -0.0721089162 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT004046 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21146880 |
| hsa-miR-484 | MIMAT0002174 | MIRT042197 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27429587 | Compensatory effects of UCP2 up-regulation with time against Genipin treatment were suggested |
| 25078983 | The protein levels of telomerase reverse transcriptase (TERT), UCP2, Akt, phosphor (p)-Akt, c-myc, and p53 were assessed by immunoblot |
| 25078983 | LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels |
| 19889414 | Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation |
| 19889414 | Therefore, we studied the association of leukocyte telomere length (LTL) with the presence of T2D, as well as the effect on the patients' LTL of plasma oxidative stress and of variation in UCP2, a gene involved in the mitochondrial production of reactive oxygen species |
| 19889414 | The patients were also genotyped for the UCP2 functional variants -866G>A and A55V |
| 19889414 | The association of the UCP2 functional promoter variant with the LTL implies a link between mitochondrial production of reactive oxygen species and shorter telomere length in T2D |
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