HCSGD entry for UCN

1. General information

Official gene symbol	UCN
Entrez ID	7349
Gene full name	urocortin
Other gene symbols	UI UROC
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0005184	Neuropeptide hormone activity	TAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005576	Extracellular region	IEA	cellular_component
GO:0006954	Inflammatory response	IEA	biological_process
GO:0006979	Response to oxidative stress	IEA	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	TAS	biological_process
GO:0007218	Neuropeptide signaling pathway	IEA	biological_process
GO:0007565	Female pregnancy	IEA	biological_process
GO:0008306	Associative learning	IEA	biological_process
GO:0009060	Aerobic respiration	IEA	biological_process
GO:0010628	Positive regulation of gene expression	IEA	biological_process
GO:0010629	Negative regulation of gene expression	IEA	biological_process
GO:0030157	Pancreatic juice secretion	IEA	biological_process
GO:0030307	Positive regulation of cell growth	IEA	biological_process
GO:0030425	Dendrite	IEA	cellular_component
GO:0030819	Positive regulation of cAMP biosynthetic process	IEA	biological_process
GO:0031175	Neuron projection development	IEA	biological_process
GO:0032099	Negative regulation of appetite	IEA	biological_process
GO:0032355	Response to estradiol	IEA	biological_process
GO:0032755	Positive regulation of interleukin-6 production	IEA	biological_process
GO:0032967	Positive regulation of collagen biosynthetic process	IEA	biological_process
GO:0033138	Positive regulation of peptidyl-serine phosphorylation	IEA	biological_process
GO:0034199	Activation of protein kinase A activity	IEA	biological_process
GO:0035483	Gastric emptying	IEA	biological_process
GO:0042756	Drinking behavior	IEA	biological_process
GO:0043066	Negative regulation of apoptotic process	IEA	biological_process
GO:0043117	Positive regulation of vascular permeability	IEA	biological_process
GO:0043196	Varicosity	IEA	cellular_component
GO:0043204	Perikaryon	IEA	cellular_component
GO:0043679	Axon terminus	IEA	cellular_component
GO:0045727	Positive regulation of translation	IEA	biological_process
GO:0045740	Positive regulation of DNA replication	IEA	biological_process
GO:0045776	Negative regulation of blood pressure	IEA	biological_process
GO:0045792	Negative regulation of cell size	IEA	biological_process
GO:0045909	Positive regulation of vasodilation	IEA	biological_process
GO:0046811	Histone deacetylase inhibitor activity	IEA	molecular_function
GO:0046888	Negative regulation of hormone secretion	IEA	biological_process
GO:0048265	Response to pain	IEA	biological_process
GO:0051384	Response to glucocorticoid	IEA	biological_process
GO:0051430	Corticotropin-releasing hormone receptor 1 binding	IEA	molecular_function
GO:0051431	Corticotropin-releasing hormone receptor 2 binding	IEA	molecular_function
GO:0051461	Positive regulation of corticotropin secretion	IEA	biological_process
GO:0051966	Regulation of synaptic transmission, glutamatergic	IEA	biological_process
GO:0060452	Positive regulation of cardiac muscle contraction	IEA	biological_process
GO:0060455	Negative regulation of gastric acid secretion	IEA	biological_process
GO:0060547	Negative regulation of necrotic cell death	IEA	biological_process
GO:0090280	Positive regulation of calcium ion import	IEA	biological_process
GO:1901215	Negative regulation of neuron death	IEA	biological_process
GO:2000252	Negative regulation of feeding behavior	IEA	biological_process
GO:2000987	Positive regulation of behavioral fear response	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.4117904449	0.6798493180	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.1468428574
GSE13712_SHEAR	Up	0.1610511670
GSE13712_STATIC	Down	-0.2012429825
GSE19018	Up	0.0365758576
GSE19899_A1	Down	-0.0901358620
GSE19899_A2	Up	0.2845182205
PubMed_21979375_A1	Down	-0.3573873184
PubMed_21979375_A2	Down	-0.2865130288
GSE35957	Down	-0.2186814362
GSE36640	Up	0.0664701981
GSE54402	Down	-0.0613161548
GSE9593	Up	0.0097670678
GSE43922	Up	0.1019983170
GSE24585	Up	0.2323799128
GSE37065	Down	-0.1655044586
GSE28863_A1	Down	-0.0342526314
GSE28863_A2	Up	0.0073246635
GSE28863_A3	Up	0.1786662507
GSE28863_A4	Up	0.1091712463
GSE48662	Up	0.7592351616

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results