HCSGD entry for UCHL3
1. General information
| Official gene symbol | UCHL3 |
|---|---|
| Entrez ID | 7347 |
| Gene full name | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
| Other gene symbols | UCH-L3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004221 | Ubiquitin thiolesterase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0030163 | Protein catabolic process | IDA | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0081450819 | 0.8653727708 | 0.2341083878 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2457792428 |
| GSE13712_SHEAR | Up | 0.7155528986 |
| GSE13712_STATIC | Up | 0.5538008475 |
| GSE19018 | Down | -0.0613566698 |
| GSE19899_A1 | Up | 1.2084580149 |
| GSE19899_A2 | Up | 1.0335870608 |
| PubMed_21979375_A1 | Up | 1.6376985839 |
| PubMed_21979375_A2 | Up | 0.7721791868 |
| GSE35957 | Down | -0.3429489915 |
| GSE36640 | Up | 0.4507771206 |
| GSE54402 | Up | 0.5159321051 |
| GSE9593 | Up | 0.4694338727 |
| GSE43922 | Up | 0.4539407076 |
| GSE24585 | Down | -0.5696690368 |
| GSE37065 | Down | -0.1688710433 |
| GSE28863_A1 | Down | -0.2462110189 |
| GSE28863_A2 | Up | 0.0854150209 |
| GSE28863_A3 | Down | -0.3823579604 |
| GSE28863_A4 | Up | 0.1829933520 |
| GSE48662 | Down | -0.2200152478 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019702 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047087 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
