HCSGD entry for UCHL1

1. General information

Official gene symbolUCHL1
Entrez ID7345
Gene full nameubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Other gene symbolsPARK5 PGP 9.5 PGP9.5 PGP95 Uch-L1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002931Response to ischemiaIEAbiological_process
GO:0004197Cysteine-type endopeptidase activityIDAmolecular_function
GO:0004221Ubiquitin thiolesterase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA ISS TAScellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0007412Axon target recognitionIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008242Omega peptidase activityIDAmolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:0016579Protein deubiquitinationIDAbiological_process
GO:0016874Ligase activityIEAmolecular_function
GO:0019233Sensory perception of painIEAbiological_process
GO:0019896Axon transport of mitochondrionIEAbiological_process
GO:0030424AxonIEAcellular_component
GO:0031694Alpha-2A adrenergic receptor bindingIPImolecular_function
GO:0042755Eating behaviorIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0048747Muscle fiber developmentIEAbiological_process
GO:0050905Neuromuscular processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22305308310.45003895370.90402897931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1377769758
GSE13712_SHEARUp0.6928313165
GSE13712_STATICUp0.5506173781
GSE19018Down-0.2603312562
GSE19899_A1Down-0.0418506856
GSE19899_A2Down-0.1816113231
PubMed_21979375_A1Down-0.7621100770
PubMed_21979375_A2Up0.0898195266
GSE35957Up0.1620733190
GSE36640Up0.8909934831
GSE54402Up0.3638750118
GSE9593Up0.2858107965
GSE43922Up0.0357739616
GSE24585Up0.0294009835
GSE37065Down-0.2606007348
GSE28863_A1Down-0.5482759887
GSE28863_A2Up0.0412828275
GSE28863_A3Down-0.1745170437
GSE28863_A4Down-0.0061924914
GSE48662Up0.0260333282

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-5pMIMAT0004949MIRT037262CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041399CLASHFunctional MTI (Weak)23622248
hsa-miR-181a-5pMIMAT0000256MIRT047324CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT048928CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.