HCSGD entry for UBE2D3

1. General information

Official gene symbolUBE2D3
Entrez ID7323
Gene full nameubiquitin-conjugating enzyme E2D 3
Other gene symbolsE2(17)KB3 UBC4/5 UBCH5C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006464Cellular protein modification processTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0010008Endosome membraneIEAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0030509BMP signaling pathwayTASbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89723433760.33195391510.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1233108235
GSE13712_SHEARUp0.3144111143
GSE13712_STATICUp0.1055050522
GSE19018Up0.0523284114
GSE19899_A1Up0.0161056194
GSE19899_A2Down-0.1949243737
PubMed_21979375_A1Down-0.2796144363
PubMed_21979375_A2Up0.0423628332
GSE35957Down-0.0021135611
GSE36640Down-0.3124168936
GSE54402Down-0.0318288474
GSE9593Down-0.0893746564
GSE43922Up0.1237000888
GSE24585Up0.0100559884
GSE37065Up0.1420646468
GSE28863_A1Up0.0263277335
GSE28863_A2Down-0.2696367367
GSE28863_A3Down-0.2442836919
GSE28863_A4Down-0.0758610052
GSE48662Down-0.3297151398

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020637ProteomicsFunctional MTI (Weak)18668040
hsa-miR-101-3pMIMAT0000099MIRT027292SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027590MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032304ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT037185CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038113CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.