HCSGD entry for UBE2D2

1. General information

Official gene symbolUBE2D2
Entrez ID7322
Gene full nameubiquitin-conjugating enzyme E2D 2
Other gene symbolsE2(17)KB2 PUBC1 UBC4 UBC4/5 UBCH5B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62256362220.70093244560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0997636450
GSE13712_SHEARDown-0.2265915813
GSE13712_STATICDown-0.1530708268
GSE19018Up0.0078996774
GSE19899_A1Down-0.0092181116
GSE19899_A2Up0.1226641838
PubMed_21979375_A1Down-0.2778117390
PubMed_21979375_A2Down-0.0134456735
GSE35957Down-0.1988808440
GSE36640Down-0.2371667587
GSE54402Up0.1906983374
GSE9593Up0.1636550291
GSE43922Up0.0859302261
GSE24585Up0.1138315561
GSE37065Up0.0601428068
GSE28863_A1Up0.1610189010
GSE28863_A2Up0.3909086042
GSE28863_A3Down-0.2639518487
GSE28863_A4Down-0.2453232606
GSE48662Up0.3252594204

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(R,R)-2,3-ButanediolDB02418 EXPT00773

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020586ProteomicsFunctional MTI (Weak)18668040
hsa-miR-215-5pMIMAT0000272MIRT024527MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026243MicroarrayFunctional MTI (Weak)19074876
hsa-let-7b-5pMIMAT0000063MIRT032280ProteomicsFunctional MTI (Weak)18668040
hsa-miR-10a-5pMIMAT0000253MIRT047680CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047862CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.