HCSGD entry for UBA1
1. General information
| Official gene symbol | UBA1 |
|---|---|
| Entrez ID | 7317 |
| Gene full name | ubiquitin-like modifier activating enzyme 1 |
| Other gene symbols | A1S9 A1S9T A1ST AMCX1 GXP1 POC20 SMAX2 UBA1A UBE1 UBE1X |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006464 | Cellular protein modification process | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008641 | Small protein activating enzyme activity | IEA | molecular_function |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1365963565 | 0.8480145511 | 0.7450889142 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1102941248 |
| GSE13712_SHEAR | Up | 0.1844465545 |
| GSE13712_STATIC | Up | 0.0338131531 |
| GSE19018 | Up | 0.2619493553 |
| GSE19899_A1 | Up | 0.0095287354 |
| GSE19899_A2 | Up | 0.6144679450 |
| PubMed_21979375_A1 | Up | 0.1920574015 |
| PubMed_21979375_A2 | Up | 0.5667535172 |
| GSE35957 | Down | -0.2352493928 |
| GSE36640 | Up | 0.1836181007 |
| GSE54402 | Up | 0.2885105257 |
| GSE9593 | Down | -0.1897661461 |
| GSE43922 | Up | 0.0037657845 |
| GSE24585 | Down | -0.1464697834 |
| GSE37065 | Down | -0.0810958752 |
| GSE28863_A1 | Up | 0.2647780479 |
| GSE28863_A2 | Up | 0.4558909752 |
| GSE28863_A3 | Down | -0.5303225672 |
| GSE28863_A4 | Down | -0.0221458525 |
| GSE48662 | Up | 0.4321899765 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Hexatantalum Dodecabromide | DB04119 | EXPT03019 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1254 | MIMAT0005905 | MIRT035858 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036044 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037737 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040312 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043196 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043523 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046237 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046712 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT047004 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047192 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050778 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051972 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16189290 | Gxp1 and glutathione reductase levels were increased in the older female cortex compared with males |
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