HCSGD entry for UBC
1. General information
Official gene symbol | UBC |
---|---|
Entrez ID | 7316 |
Gene full name | ubiquitin C |
Other gene symbols | HMG20 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
GO:0000187 | Activation of MAPK activity | TAS | biological_process |
GO:0000209 | Protein polyubiquitination | TAS | biological_process |
GO:0000278 | Mitotic cell cycle | TAS | biological_process |
GO:0002020 | Protease binding | IPI | molecular_function |
GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
GO:0002479 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | biological_process |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005654 | Nucleoplasm | TAS | cellular_component |
GO:0005829 | Cytosol | TAS | cellular_component |
GO:0005886 | Plasma membrane | TAS | cellular_component |
GO:0006281 | DNA repair | TAS | biological_process |
GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
GO:0006915 | Apoptotic process | TAS | biological_process |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | biological_process |
GO:0007141 | Male meiosis I | IEA | biological_process |
GO:0007144 | Female meiosis I | IEA | biological_process |
GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
GO:0007219 | Notch signaling pathway | TAS | biological_process |
GO:0007220 | Notch receptor processing | TAS | biological_process |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
GO:0007254 | JNK cascade | TAS | biological_process |
GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
GO:0008585 | Female gonad development | IEA | biological_process |
GO:0010008 | Endosome membrane | TAS | cellular_component |
GO:0010467 | Gene expression | TAS | biological_process |
GO:0010992 | Ubiquitin homeostasis | IEA | biological_process |
GO:0016032 | Viral process | TAS | biological_process |
GO:0016070 | RNA metabolic process | TAS | biological_process |
GO:0016071 | MRNA metabolic process | TAS | biological_process |
GO:0016197 | Endosomal transport | TAS | biological_process |
GO:0019068 | Virion assembly | TAS | biological_process |
GO:0019082 | Viral protein processing | TAS | biological_process |
GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
GO:0021888 | Hypothalamus gonadotrophin-releasing hormone neuron development | IEA | biological_process |
GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
GO:0032479 | Regulation of type I interferon production | TAS | biological_process |
GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
GO:0034220 | Ion transmembrane transport | TAS | biological_process |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
GO:0045087 | Innate immune response | TAS | biological_process |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
GO:0055085 | Transmembrane transport | TAS | biological_process |
GO:0060613 | Fat pad development | IEA | biological_process |
GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
GO:0070423 | Nucleotide-binding oligomerization domain containing signaling pathway | TAS | biological_process |
GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
GO:0072520 | Seminiferous tubule development | IEA | biological_process |
GO:0097009 | Energy homeostasis | IEA | biological_process |
GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.3306778770 | 0.9729336195 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.1266370530 |
GSE13712_SHEAR | Up | 0.1112708103 |
GSE13712_STATIC | Up | 0.1670806742 |
GSE19018 | Up | 0.1656893248 |
GSE19899_A1 | Up | 0.0495895690 |
GSE19899_A2 | Down | -0.0050104435 |
PubMed_21979375_A1 | Up | 0.3804805390 |
PubMed_21979375_A2 | Down | -0.1204226449 |
GSE35957 | Down | -0.0008321570 |
GSE36640 | Up | 0.3137384040 |
GSE54402 | Up | 0.1289297548 |
GSE9593 | Up | 0.3128280114 |
GSE43922 | Down | -0.0131433583 |
GSE24585 | Up | 0.0299696257 |
GSE37065 | Up | 0.0834952225 |
GSE28863_A1 | - | - |
GSE28863_A2 | - | - |
GSE28863_A3 | - | - |
GSE28863_A4 | - | - |
GSE48662 | Down | -0.1103007578 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
N-Formylmethionine | DB04464 | EXPT01455 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-24-3p | MIMAT0000080 | MIRT030628 | qRT-PCR | Functional MTI (Weak) | 19748357 |
hsa-miR-877-5p | MIMAT0004949 | MIRT037302 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-296-3p | MIMAT0004679 | MIRT038409 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-769-3p | MIMAT0003887 | MIRT039075 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-615-3p | MIMAT0003283 | MIRT039711 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-324-3p | MIMAT0000762 | MIRT042909 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-221-3p | MIMAT0000278 | MIRT046896 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-18a-5p | MIMAT0000072 | MIRT050710 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
24505313 | To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene SENEX and relevant apoptosis gene mRNA expression in sorted CD4+CD25(hi) Tregs from aged UBC donors, evaluated serum cytokine profiles related to tumor immunopathology, and further explored the relationship between SENEX expression, apoptosis gene expression and cytokine secretion |
24505313 | After having silenced down SENEX gene expression with RNA interference, we also evaluated the cellular apoptosis of Tregs sorted from aged UBC patients in response to H(2)O(2)-mediated stress |
24505313 | Our data indicated that upregulated SENEX mRNA expression in Tregs of aged UBC patients was correlated with pro-apoptotic gene expression and cytokine concentration |
Entries Per Page
Displaying Page of