HCSGD entry for UBC


1. General information

Official gene symbolUBC
Entrez ID7316
Gene full nameubiquitin C
Other gene symbolsHMG20
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000187Activation of MAPK activityTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006281DNA repairTASbiological_process
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0007141Male meiosis IIEAbiological_process
GO:0007144Female meiosis IIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008585Female gonad developmentIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0010467Gene expressionTASbiological_process
GO:0010992Ubiquitin homeostasisIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016197Endosomal transportTASbiological_process
GO:0019068Virion assemblyTASbiological_process
GO:0019082Viral protein processingTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0021888Hypothalamus gonadotrophin-releasing hormone neuron developmentIEAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0032479Regulation of type I interferon productionTASbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060613Fat pad developmentIEAbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
GO:0072520Seminiferous tubule developmentIEAbiological_process
GO:0097009Energy homeostasisIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33067787700.97293361950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1266370530
GSE13712_SHEARUp0.1112708103
GSE13712_STATICUp0.1670806742
GSE19018Up0.1656893248
GSE19899_A1Up0.0495895690
GSE19899_A2Down-0.0050104435
PubMed_21979375_A1Up0.3804805390
PubMed_21979375_A2Down-0.1204226449
GSE35957Down-0.0008321570
GSE36640Up0.3137384040
GSE54402Up0.1289297548
GSE9593Up0.3128280114
GSE43922Down-0.0131433583
GSE24585Up0.0299696257
GSE37065Up0.0834952225
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1103007578

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-FormylmethionineDB04464 EXPT01455

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030628qRT-PCRFunctional MTI (Weak)19748357
hsa-miR-877-5pMIMAT0004949MIRT037302CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038409CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039075CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039711CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042909CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046896CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050710CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24505313To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene SENEX and relevant apoptosis gene mRNA expression in sorted CD4+CD25(hi) Tregs from aged UBC donors, evaluated serum cytokine profiles related to tumor immunopathology, and further explored the relationship between SENEX expression, apoptosis gene expression and cytokine secretion
24505313After having silenced down SENEX gene expression with RNA interference, we also evaluated the cellular apoptosis of Tregs sorted from aged UBC patients in response to H(2)O(2)-mediated stress
24505313Our data indicated that upregulated SENEX mRNA expression in Tregs of aged UBC patients was correlated with pro-apoptotic gene expression and cytokine concentration
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