HCSGD entry for U2AF1
1. General information
| Official gene symbol | U2AF1 |
|---|---|
| Entrez ID | 7307 |
| Gene full name | U2 small nuclear RNA auxiliary factor 1 |
| Other gene symbols | FP793 RN RNU2AF1 U2AF35 U2AFBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0015030 | Cajal body | TAS | cellular_component |
| GO:0016607 | Nuclear speck | ISS | cellular_component |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050733 | RS domain binding | IEA | molecular_function |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9775747198 | 0.0257944493 | 0.9999902473 | 0.3083268392 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1575258513 |
| GSE13712_SHEAR | Down | -0.0191428994 |
| GSE13712_STATIC | Down | -0.0585310267 |
| GSE19018 | Down | -0.5632639511 |
| GSE19899_A1 | Down | -0.4033051639 |
| GSE19899_A2 | Down | -0.6456689033 |
| PubMed_21979375_A1 | Down | -0.6205232816 |
| PubMed_21979375_A2 | Down | -0.6346942132 |
| GSE35957 | Down | -0.1856963593 |
| GSE36640 | Down | -0.6901071795 |
| GSE54402 | Up | 0.0433436493 |
| GSE9593 | Down | -0.3691522438 |
| GSE43922 | Down | -0.4209689978 |
| GSE24585 | Down | -0.2243315707 |
| GSE37065 | Down | -0.0379715387 |
| GSE28863_A1 | Up | 0.1849878474 |
| GSE28863_A2 | Up | 0.1768506758 |
| GSE28863_A3 | Up | 0.2905745008 |
| GSE28863_A4 | Down | -0.0026234440 |
| GSE48662 | Down | -0.1310545803 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27147278 | Prominent examples include aberrations in cytokines and their signaling pathways (such as tumor necrosis factor-alpha, interferon-gamma, SMAD proteins), mutations in genes encoding the RNA splicing machinery (SF3B1, SRSF2, ZRSR2, and U2AF1 genes), mutations in genes disrupting the epigenetic machinery (TET2, DNMT3A, DNMT3B, EZH2, ASXL1) |
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