HCSGD entry for TYR

1. General information

Official gene symbolTYR
Entrez ID7299
Gene full nametyrosinase
Other gene symbolsCMM8 OCA1A OCAIA SHEP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004503Monophenol monooxygenase activityIDAmolecular_function
GO:0005507Copper ion bindingIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeTAScellular_component
GO:0005798Golgi-associated vesicleTAScellular_component
GO:0006583Melanin biosynthetic process from tyrosineTASbiological_process
GO:0006726Eye pigment biosynthetic processTASbiological_process
GO:0007601Visual perceptionTASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0033162Melanosome membraneIEAcellular_component
GO:0042470MelanosomeISScellular_component
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0046982Protein heterodimerization activityISSmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048538Thymus developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47384103570.94871662170.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0136385540
GSE13712_SHEARUp0.0613872384
GSE13712_STATICDown-0.0994985673
GSE19018Up0.1971723963
GSE19899_A1Up0.0042950372
GSE19899_A2Up0.0176885894
PubMed_21979375_A1Up0.1024120873
PubMed_21979375_A2Up0.1256241860
GSE35957Up0.1543061950
GSE36640Down-0.0395152491
GSE54402Up0.0893304460
GSE9593Up0.0454188786
GSE43922Up0.0805718587
GSE24585Up0.1706775202
GSE37065Down-0.0072957908
GSE28863_A1Up0.1472369752
GSE28863_A2Up0.0958706481
GSE28863_A3Up0.0676808819
GSE28863_A4Up0.0015155794
GSE48662Up0.0197689367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
MimosineDB01055 APRD00647
HydroquinoneDB09526 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26731545TE increased the mRNA expression of collagen-I, elastin, superoxide dismutase (SOD-2), aquaporin-3 (AQP-3), filaggrin, involucrin, transglutaminase in HDF or HaCaT cells, and decreased the mRNA levels of tyrosinase in B16F10 cells
26056007After 2 days of culture in the presence of Wnt-CM, proliferation of B16 melanoma cells was inhibited, whereas tyrosinase activity was increased
16280018CONCLUSIONS: These findings suggest that IL-1alpha secretion increases as cells grow older, and the increased secretion of IL-1alpha by aged keratinocytes may stimulate HGF production in dermal fibroblasts paracrinely and ET-1 production in keratinocytes autocrinely, which stimulates melanocyte proliferation and induces an increase of tyrosinase activity in melanocytes
8099831The results of studies on seeding density effect and serial Dopa reaction on the melanocytes of normal individuals reveal that the use of tyrosinase activity as the assessment parameter requires the use of melanocytes cultured for less than five months at a seeding density of less than 4 x 10(4) cells/cm2
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