HCSGD entry for TYMS

1. General information

Official gene symbolTYMS
Entrez ID7298
Gene full namethymidylate synthetase
Other gene symbolsHST422 TMS TS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000083Regulation of transcription involved in G1/S transition of mitotic cell cycleTASbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000278Mitotic cell cycleTASbiological_process
GO:0003729MRNA bindingIEAmolecular_function
GO:0004799Thymidylate synthase activityTASmolecular_function
GO:0005542Folic acid bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIDAcellular_component
GO:0005759Mitochondrial matrixIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005976Polysaccharide metabolic processIEAbiological_process
GO:0006139Nucleobase-containing compound metabolic processTASbiological_process
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006231DTMP biosynthetic processIEAbiological_process
GO:0006235DTTP biosynthetic processIEAbiological_process
GO:0006260DNA replicationNASbiological_process
GO:0006281DNA repairNASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0009157Deoxyribonucleoside monophosphate biosynthetic processTASbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0019088Immortalization of host cell by virusIEAbiological_process
GO:0019860Uracil metabolic processIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0046078DUMP metabolic processIEAbiological_process
GO:0046134Pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0046653Tetrahydrofolate metabolic processIEAbiological_process
GO:0046683Response to organophosphorusIEPbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0048037Cofactor bindingIEAmolecular_function
GO:0048589Developmental growthIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0060574Intestinal epithelial cell maturationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89144174230.00011012120.99999024730.0190690789

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8973589477
GSE13712_SHEARUp0.1854531002
GSE13712_STATICUp0.0018058501
GSE19018Down-0.0336925550
GSE19899_A1Down-2.2946967407
GSE19899_A2Down-2.6764230743
PubMed_21979375_A1Down-2.4320966887
PubMed_21979375_A2Down-3.4497047217
GSE35957Down-3.0818982236
GSE36640Down-2.8505141256
GSE54402Down-0.8298275582
GSE9593Down-1.1114914140
GSE43922Down-2.2967209534
GSE24585Up0.0576985529
GSE37065Down-0.3837726735
GSE28863_A1Up0.1675705065
GSE28863_A2Up0.9187719066
GSE28863_A3Down-0.1360543789
GSE28863_A4Up0.3822534559
GSE48662Down-1.5235024203

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RaltitrexedDB00293 APRD00430 | EXPT01092
TrifluridineDB00432 APRD01275
TrimethoprimDB00440 APRD00103
GemcitabineDB00441 APRD00201
FluorouracilDB00544 APRD00516 | EXPT03204
PemetrexedDB00642 APRD00573 | EXPT02075
10-Propargyl-5,8-Dideazafolic AcidDB03541 EXPT00839
2'-deoxyuridylic acidDB03800 EXPT03187
S,S-(2-Hydroxyethyl)ThiocysteineDB04530 EXPT00954
NB1011DB05116 -
ANX-510DB05308 -
OSI-7904LDB05457 -
6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINEDB07577 -
N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamideDB08478 -
N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamideDB08479 -
6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINEDB08734 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT001582pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-193b-3pMIMAT0002819MIRT016485MicroarrayFunctional MTI (Weak)20304954
hsa-miR-34a-5pMIMAT0000255MIRT025487ProteomicsFunctional MTI (Weak)21566225
hsa-miR-26b-5pMIMAT0000083MIRT029608MicroarrayFunctional MTI (Weak)19088304
hsa-miR-615-3pMIMAT0003283MIRT040293CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040968CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042289CLASHFunctional MTI (Weak)23622248
hsa-miR-194-5pMIMAT0000460MIRT044879CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048693CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

10799836This difference is much higher than those observed for classical enzymatic targets of chemotherapy such as thymidylate synthetase, dihydrofolate reductase and topoisomerases
2632284We have also compared the enzyme activities of two late G1/S genes, thymidine kinase and thymidylate synthetase, in young and old cells following serum stimulation
2632284Results also demonstrate that aging of IMR-90 cells was accompanied by significant decrease of both thymidine kinase and thymidylate synthetase activities
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