HCSGD entry for TXN
1. General information
| Official gene symbol | TXN |
|---|---|
| Entrez ID | 7295 |
| Gene full name | thioredoxin |
| Other gene symbols | TRDX TRX TRX1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006662 | Glycerol ether metabolic process | IEA | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009314 | Response to radiation | IDA | biological_process |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0015037 | Peptide disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0033158 | Regulation of protein import into nucleus, translocation | IDA | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0043388 | Positive regulation of DNA binding | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0046826 | Negative regulation of protein export from nucleus | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1858712739 | 0.7452885795 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3567047572 |
| GSE13712_SHEAR | Up | 0.2662272835 |
| GSE13712_STATIC | Up | 0.3667440950 |
| GSE19018 | Up | 0.0807691820 |
| GSE19899_A1 | Up | 0.3464256881 |
| GSE19899_A2 | Down | -0.1757639920 |
| PubMed_21979375_A1 | Up | 0.3094908416 |
| PubMed_21979375_A2 | Down | -0.2043242821 |
| GSE35957 | Up | 0.1390534245 |
| GSE36640 | Up | 0.1467269906 |
| GSE54402 | Up | 0.1221812576 |
| GSE9593 | Down | -0.0109480162 |
| GSE43922 | Down | -0.0067399410 |
| GSE24585 | Down | -0.2588777159 |
| GSE37065 | Down | -0.0348871467 |
| GSE28863_A1 | Up | 0.0132448589 |
| GSE28863_A2 | Down | -0.0015684696 |
| GSE28863_A3 | Down | -0.1596826871 |
| GSE28863_A4 | Up | 0.3318316510 |
| GSE48662 | Down | -0.2000131528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035966 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045602 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046747 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24305779 | Young workers had higher reactive oxygen species levels, higher superoxide dismutase and thioredoxin reductase activities as well as lower catalase and glutathione peroxidase activities compared to old workers |
| 23738955 | Young queens had lower ROS levels, lower superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and higher thioredoxin reductase (TR) activity compared to old queens |
| 23274001 | 77 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1) |
| 22414001 | Silencing thioredoxin induces liver cancer cell senescence under hypoxia |
| 22414001 | AIM: Although thioredoxin 1 (TXN) has pleiotropic cellular functions as a redox-sensitive protein, very little is known about its role in tumor survival and growth under hypoxia |
| 22414001 | MHCC97H hepatocellular carcinoma cells have a high metastatic potential and high thioredoxin expression levels compared with their parent cell line, MHCC97 |
| 22414001 | Thus, we used this cell line to explore the functional connections between TXN and hypoxia |
| 22414001 | METHODS: MHCC97H cells were cultured under normoxia and hypoxia for specific periods after nucleofection with TXN siRNA or control siRNA |
| 22414001 | RESULTS: beta-phenylethyl isothiocyanate treatment shifted reduced TXN to oxidized TXN in MHCC97H cells |
| 22414001 | Although silencing of TXN via siRNA had no effect on the PEITC sensitivity of the cells, it suppressed cell proliferation and colony formation under both normoxia and hypoxia |
| 22414001 | Under hypoxia, silencing TXN did not induce apoptosis but induced DNA damage response and cellular senescence |
| 22414001 | CONCLUSIONS: High TXN levels in MHCC97H cells protect them from DNA damage and cellular senescence under hypoxia |
| 22414001 | Targeting TXN might enhance the chemotherapeutic effects of some DNA-damaging agents against hepatocellular carcinoma |
| 19820694 | Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence |
| 19820694 | Thioredoxin reductase 1 (TrxR1) is an important antioxidant enzyme that controls cellular redox homeostasis |
| 19486941 | Signaling circuits may be segregated in organelles or other subcellular domains with distinct redox states, permitting them to respond independently to changes in the oxidation state of two major thiol reductants, glutathione and thioredoxin |
| 16024017 | Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation |
| 15680234 | Protein-bound methionine sulfoxide diastereoisomers S and R are repaired by the combined action of the enzymes MsrA and MsrB that are subsequently regenerated by thioredoxin/thioredoxin reductase |
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