HCSGD entry for TXK
1. General information
| Official gene symbol | TXK |
|---|---|
| Entrez ID | 7294 |
| Gene full name | TXK tyrosine kinase |
| Other gene symbols | BTKL PSCTK5 PTK4 RLK TKL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001012 | RNA polymerase II regulatory region DNA binding | IDA | molecular_function |
| GO:0001816 | Cytokine production | ISS | biological_process |
| GO:0001865 | NK T cell differentiation | IEA | biological_process |
| GO:0002250 | Adaptive immune response | ISS | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | ISS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0032609 | Interferon-gamma production | IEA | biological_process |
| GO:0032633 | Interleukin-4 production | IEA | biological_process |
| GO:0032729 | Positive regulation of interferon-gamma production | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0050852 | T cell receptor signaling pathway | ISS | biological_process |
| GO:0060335 | Positive regulation of interferon-gamma-mediated signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5962571217 | 0.8830080088 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0659851011 |
| GSE13712_SHEAR | Up | 0.1586799129 |
| GSE13712_STATIC | Up | 0.3386705223 |
| GSE19018 | Down | -0.0099018868 |
| GSE19899_A1 | Down | -0.0884784221 |
| GSE19899_A2 | Down | -0.0857316218 |
| PubMed_21979375_A1 | Up | 0.1370570334 |
| PubMed_21979375_A2 | Down | -0.1716245084 |
| GSE35957 | Up | 0.0820002930 |
| GSE36640 | Up | 0.1629242307 |
| GSE54402 | Up | 0.0694884792 |
| GSE9593 | Up | 0.0968174557 |
| GSE43922 | Up | 0.0167597665 |
| GSE24585 | Up | 0.1618412258 |
| GSE37065 | Up | 0.0490549590 |
| GSE28863_A1 | Up | 0.0271072068 |
| GSE28863_A2 | Down | -0.0600644186 |
| GSE28863_A3 | Up | 0.0926865988 |
| GSE28863_A4 | Up | 0.0176826211 |
| GSE48662 | Down | -0.0484897698 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029543 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
