HCSGD entry for TNFSF4

1. General information

Official gene symbolTNFSF4
Entrez ID7292
Gene full nametumor necrosis factor (ligand) superfamily, member 4
Other gene symbolsCD134L CD252 GP34 OX-40L OX4OL TXGP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002215Defense response to nematodeISSbiological_process
GO:0002526Acute inflammatory responseISSbiological_process
GO:0002726Positive regulation of T cell cytokine productionISSbiological_process
GO:0002819Regulation of adaptive immune responseISSbiological_process
GO:0002830Positive regulation of type 2 immune responseISSbiological_process
GO:0002891Positive regulation of immunoglobulin mediated immune responseISSbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009615Response to virusISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0032689Negative regulation of interferon-gamma productionISSbiological_process
GO:0032700Negative regulation of interleukin-17 productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDAbiological_process
GO:0032733Positive regulation of interleukin-10 productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032736Positive regulation of interleukin-13 productionISSbiological_process
GO:0032743Positive regulation of interleukin-2 productionIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIDAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032813Tumor necrosis factor receptor superfamily bindingISSmolecular_function
GO:0035709Memory T cell activationISSbiological_process
GO:0035712T-helper 2 cell activationISSbiological_process
GO:0035713Response to nitrogen dioxideISSbiological_process
GO:0035714Cellular response to nitrogen dioxideIEAbiological_process
GO:0035783CD4-positive, alpha-beta T cell costimulationIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042104Positive regulation of activated T cell proliferationIEAbiological_process
GO:0043372Positive regulation of CD4-positive, alpha-beta T cell differentiationISSbiological_process
GO:0043382Positive regulation of memory T cell differentiationISSbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0045590Negative regulation of regulatory T cell differentiationISSbiological_process
GO:0045626Negative regulation of T-helper 1 cell differentiationISSbiological_process
GO:0045630Positive regulation of T-helper 2 cell differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationISSbiological_process
GO:0050710Negative regulation of cytokine secretionIEAbiological_process
GO:0050727Regulation of inflammatory responseISSbiological_process
GO:0050729Positive regulation of inflammatory responseIDAbiological_process
GO:0050871Positive regulation of B cell activationISSbiological_process
GO:0051024Positive regulation of immunoglobulin secretionISSbiological_process
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071380Cellular response to prostaglandin E stimulusIDAbiological_process
GO:0071954Chemokine (C-C motif) ligand 11 productionISSbiological_process
GO:1900281Positive regulation of CD4-positive, alpha-beta T cell costimulationISSbiological_process
GO:2000568Positive regulation of memory T cell activationIEAbiological_process
GO:2000570Positive regulation of T-helper 2 cell activationIEAbiological_process
GO:2000572Positive regulation of interleukin-4-dependent isotype switching to IgE isotypesISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96014288210.00004151440.99999024730.0109660000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.1956528615
GSE13712_SHEARDown-0.7445853665
GSE13712_STATICDown-0.7538137735
GSE19018Up0.1860201286
GSE19899_A1Down-3.4532680349
GSE19899_A2Down-5.2131186867
PubMed_21979375_A1Down-5.1648483093
PubMed_21979375_A2Down-7.2033477702
GSE35957Up0.0218608222
GSE36640Up0.1974472706
GSE54402Down-3.7453735718
GSE9593Up0.2009364480
GSE43922Down-3.3194991980
GSE24585Up0.1500075051
GSE37065Up0.1925691862
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1595100360

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.