HCSGD entry for TWIST1

1. General information

Official gene symbolTWIST1
Entrez ID7291
Gene full nametwist basic helix-loop-helix transcription factor 1
Other gene symbolsACS3 BPES2 BPES3 CRS1 SCS TWIST bHLHa38
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0001503OssificationTASbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0003180Aortic valve morphogenesisIMPbiological_process
GO:0003183Mitral valve morphogenesisIEAbiological_process
GO:0003203Endocardial cushion morphogenesisIEAbiological_process
GO:0003253Cardiac neural crest cell migration involved in outflow tract morphogenesisIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030500Regulation of bone mineralizationIMPbiological_process
GO:0032000Positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0033128Negative regulation of histone phosphorylationIMPbiological_process
GO:0035067Negative regulation of histone acetylationIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035359Negative regulation of peroxisome proliferator activated receptor signaling pathwayIEAbiological_process
GO:0042473Outer ear morphogenesisTASbiological_process
GO:0042476OdontogenesisIEAbiological_process
GO:0042733Embryonic digit morphogenesisTASbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0045668Negative regulation of osteoblast differentiationIMPbiological_process
GO:0045766Positive regulation of angiogenesisNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048642Negative regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIMPbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060363Cranial suture morphogenesisTASbiological_process
GO:0060900Embryonic camera-type eye formationIMPbiological_process
GO:0061029Eyelid development in camera-type eyeIMPbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071456Cellular response to hypoxiaIMPbiological_process
GO:0071639Positive regulation of monocyte chemotactic protein-1 productionIMPbiological_process
GO:2000147Positive regulation of cell motilityIMP NASbiological_process
GO:2000276Negative regulation of oxidative phosphorylation uncoupler activityIEAbiological_process
GO:2000679Positive regulation of transcription regulatory region DNA bindingIMPbiological_process
GO:2000773Negative regulation of cellular senescenceIMPbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIMPbiological_process
GO:2000780Negative regulation of double-strand break repairIMPbiological_process
GO:2000793Cell proliferation involved in heart valve developmentIMPbiological_process
GO:2000802Positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88630484780.00799509140.99999024730.1782256128

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0176828720
GSE13712_SHEARDown-0.2895206291
GSE13712_STATICDown-0.0789648203
GSE19018Down-0.5215926561
GSE19899_A1Down-0.2094784195
GSE19899_A2Down-1.2007454556
PubMed_21979375_A1Down-0.4714653343
PubMed_21979375_A2Down-1.3822113101
GSE35957Down-1.6646981294
GSE36640Down-0.5051743613
GSE54402Down-0.5176914627
GSE9593Down-1.1327844250
GSE43922Down-0.1387522499
GSE24585Up0.3861763279
GSE37065Up0.3132323495
GSE28863_A1Up0.7714102425
GSE28863_A2Up0.1142388985
GSE28863_A3Up0.0774980464
GSE28863_A4Down-0.0949235556
GSE48662Down-0.1857874355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-214-3pMIMAT0000271MIRT006731Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22540680
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26941359In addition, CD146 suppression in hUCB-MSCs caused downregulation of other cellular senescence regulators, including Bmi-1, Id1, and Twist1
26657143Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)
26657143Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders, suggesting that SCs play a causative role in certain age-related pathologies
26657143Thus, a 'senolytic' pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span
26657143We show that ABT263 selectively kills SCs in culture in a cell type- and species-independent manner by inducing apoptosis
26657143Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs)
26657143Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells
24849235In the present review, we summarize the age-related alterations found in different tissue SC populations, highlighting recently identified changes in aged HFSCs (hair-follicle SCs) in the skin
23810552In this study, we explore the chromatin features of adult skeletal muscle stem cells, or satellite cells (SCs), which reside predominantly in a quiescent state in fully developed limb muscles of both young and aged mice
23810552Using a ChIP-seq approach to obtain global epigenetic profiles of quiescent SCs (QSCs), we show that QSCs possess a permissive chromatin state in which few genes are epigenetically repressed by Polycomb group (PcG)-mediated histone 3 lysine 27 trimethylation (H3K27me3), and a large number of genes encoding regulators that specify nonmyogenic lineages are demarcated by bivalent domains at their transcription start sites (TSSs)
23644284ANAs depend on proliferating Schwann cells (SCs) from host tissue to support axonal regeneration
23644284Populating longer ANAs places a greater proliferative demand on host SCs that may stress host SCs, resulting in senescence
23644284We also evaluated the presence of senescent SCs within both graft types
23644284Lastly, electron microscopy (EM) was used to qualitatively assess senescence-associated changes in chromatin of SCs in each graft type
23644284EM demonstrated an increase in the presence of SCs with abnormal chromatin in isografts and ANAs of increasing graft length
22654667Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis
22654667We demonstrate in both a novel transgenic mutant Kras lung cancer mouse model and in human lung tumors that the inhibition of Twist1 restores a senescence program inducing the loss of a neoplastic phenotype
22654667The Twist1 gene encodes for a transcription factor that is essential during embryogenesis
22654667Twist1 has been suggested to play an important role during tumor progression
22654667However, there is no in vivo evidence that Twist1 plays a role in autochthonous tumorigenesis
22654667Through two novel transgenic mouse models, we show that Twist1 cooperates with Kras(G12D) to markedly accelerate lung tumorigenesis by abrogating cellular senescence programs and promoting the progression from benign adenomas to adenocarcinomas
22654667Moreover, the suppression of Twist1 to physiological levels is sufficient to cause Kras mutant lung tumors to undergo senescence and lose their neoplastic features
22654667Finally, we analyzed more than 500 human tumors to demonstrate that TWIST1 is frequently overexpressed in primary human lung tumors
22654667The suppression of TWIST1 in human lung cancer cells also induced cellular senescence
22654667Hence, TWIST1 is a critical regulator of cellular senescence programs, and the suppression of TWIST1 in human tumors may be an effective example of pro-senescence therapy
21765040Furthermore, overexpression of Twist1 prevented CADPE-induced cell senescence in tumor cells
21240672Somatic cellular senescence (SCS) describes the limited ability of cells to divide
21240672Normally, SCS is associated with physiological aging, but evidence suggests that it may play a role in disease progression, even in young patients
21240672This review summarizes what is known about SCS in the kidney with aging and disease
21240672As most patients with chronic kidney disease (CKD) also develop cardiovascular complications, a second focus of this review deals with the role of SCS in cardiovascular disease
21240672Also, as SCS seems to accelerate CKD and cardiovascular disease progression, developing strategies for new treatment options that overcome SCS or protect a patient from it represents an exciting challenge
18772311The maintenance of genome integrity in stem cells (SCs) is critical for preventing cancer formation and cellular senescence
18772311The immortal strand hypothesis postulates that SCs protect their genome by keeping the same DNA strand throughout life by asymmetrical cell divisions, thus avoiding accumulation of mutations that can arise during DNA replication
18772311In this study, we revisited this long-standing hypothesis, by analyzing how multipotent hair follicle (HF) SCs segregate their DNA strands during morphogenesis, skin homeostasis, and SC activation
18772311We used three different in vivo approaches to determine how HF SCs segregate their DNA strand during cell divisions
18772311Double-labeling studies using pulse-chase experiments during morphogenesis and the first adult hair cycle showed that HF SCs incorporate two different nucleotide analogs, contradictory to the immortal strand hypothesis
18772311The co-segregation of DNA and chromatin labeling during pulse-chase experiments demonstrated that label retention in HF SCs is rather a mark of relative quiescence
18772311Moreover, DNA labeling of adult SCs, similar to labeling during morphogenesis, also resulted in label retention in HF SCs, indicating that chromosome segregation occurs randomly in most of these cells
18772311Altogether, our results demonstrate that DNA strand segregation occurs randomly in the majority of HF SCs during development, tissue homeostasis, and following SC activation
8892981We have recently reported the cloning and characterization of the human twist gene (H-twist), which encodes an evolutionarily conserved helix-loop-helix transcription factor
8892981We now report on the differential expression of H-twist as a function of in vitro life span in human diploid fibroblasts
8892981H-twist was found to be expressed at a relatively high level in quiescent young cells
8892981Addition of fresh serum to young G0 cultures results in a rapid repression of H-twist mRNA expression
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