HCSGD entry for D2HGDH

1. General information

Official gene symbolD2HGDH
Entrez ID728294
Gene full nameD-2-hydroxyglutarate dehydrogenase
Other gene symbolsD2HGD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003824Catalytic activityIEAmolecular_function
GO:0005739MitochondrionISScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:00061032-oxoglutarate metabolic processTASbiological_process
GO:0008762UDP-N-acetylmuramate dehydrogenase activityIEAmolecular_function
GO:0010042Response to manganese ionISSbiological_process
GO:0010043Response to zinc ionISSbiological_process
GO:0032025Response to cobalt ionISSbiological_process
GO:0032026Response to magnesium ionISSbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044267Cellular protein metabolic processISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050660Flavin adenine dinucleotide bindingIEAmolecular_function
GO:0051592Response to calcium ionISSbiological_process
GO:0051990(R)-2-hydroxyglutarate dehydrogenase activityISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65236876640.26325252080.99999024730.9853625711

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0013581455
GSE13712_SHEARDown-0.3426315130
GSE13712_STATICDown-0.1535794317
GSE19018Up0.2252563158
GSE19899_A1Down-0.2746613217
GSE19899_A2Up0.5693284699
PubMed_21979375_A1Down-0.9324032525
PubMed_21979375_A2Up0.2718131385
GSE35957Down-0.3270393606
GSE36640Up0.2059840555
GSE54402Down-0.0583153028
GSE9593Down-0.0760223435
GSE43922Up0.0689754335
GSE24585Down-0.1317191035
GSE37065Down-0.1489269013
GSE28863_A1Down-0.0189772363
GSE28863_A2Down-0.0259056944
GSE28863_A3Up0.1418663631
GSE28863_A4Up0.1572332329
GSE48662Down-0.0369691997

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT047376CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.