HCSGD entry for TTK
1. General information
| Official gene symbol | TTK |
|---|---|
| Entrez ID | 7272 |
| Gene full name | TTK protein kinase |
| Other gene symbols | CT96 ESK MPH1 MPS1 MPS1L1 PYT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005819 | Spindle | TAS | cellular_component |
| GO:0007051 | Spindle organization | TAS | biological_process |
| GO:0007052 | Mitotic spindle organization | TAS | biological_process |
| GO:0007094 | Mitotic spindle assembly checkpoint | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | TAS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9408544432 | 0.0000059800 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.5546803871 |
| GSE13712_SHEAR | Down | -0.5695917187 |
| GSE13712_STATIC | Down | -1.1777376574 |
| GSE19018 | Down | -0.0549254249 |
| GSE19899_A1 | Down | -1.9952217068 |
| GSE19899_A2 | Down | -4.7004069177 |
| PubMed_21979375_A1 | Down | -2.6425315859 |
| PubMed_21979375_A2 | Down | -7.3719516892 |
| GSE35957 | Down | -5.1078861115 |
| GSE36640 | Down | -5.3640169945 |
| GSE54402 | Down | -1.2713939088 |
| GSE9593 | Down | -2.3774863248 |
| GSE43922 | Down | -3.1986612196 |
| GSE24585 | Down | -0.3005639867 |
| GSE37065 | Down | -0.7625549044 |
| GSE28863_A1 | Down | -0.7897740281 |
| GSE28863_A2 | Up | 2.4123936622 |
| GSE28863_A3 | Down | -0.9749213873 |
| GSE28863_A4 | Up | 0.0580905730 |
| GSE48662 | Down | -1.7776815807 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One | DB01782 | EXPT00232 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-376a-5p | MIMAT0003386 | MIRT001746 | Luciferase reporter assay | Functional MTI | 17322061 |
| hsa-miR-376a-3p | MIMAT0000729 | MIRT019665 | Reporter assay | Functional MTI | 17322061 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024895 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026393 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-376a-5p | MIMAT0003386 | 1 | hsa-miR-376a* | 17322061 | |||
| hsa-miR-376a-5p | MIMAT0003386 | 2 | hsa-miR-376a* | 17322061 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
