HCSGD entry for PHLDA2
1. General information
| Official gene symbol | PHLDA2 |
|---|---|
| Entrez ID | 7262 |
| Gene full name | pleckstrin homology-like domain, family A, member 2 |
| Other gene symbols | BRW1C BWR1C HLDA2 IPL TSSC3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0045995 | Regulation of embryonic development | IEA | biological_process |
| GO:0070873 | Regulation of glycogen metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0133496258 | 0.9193294746 | 0.2880620492 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3078900921 |
| GSE13712_SHEAR | Up | 0.1171049075 |
| GSE13712_STATIC | Up | 0.3047952543 |
| GSE19018 | Down | -0.4509047908 |
| GSE19899_A1 | Up | 0.1750199737 |
| GSE19899_A2 | Up | 0.6032270797 |
| PubMed_21979375_A1 | Up | 1.6393285041 |
| PubMed_21979375_A2 | Up | 0.0616734282 |
| GSE35957 | Down | -0.0681796013 |
| GSE36640 | Up | 0.4672744279 |
| GSE54402 | Up | 0.9294149841 |
| GSE9593 | Up | 0.2422448546 |
| GSE43922 | Up | 0.7202756689 |
| GSE24585 | Up | 0.1164100358 |
| GSE37065 | Up | 0.0603816946 |
| GSE28863_A1 | Down | -0.6169761828 |
| GSE28863_A2 | Up | 0.0334775341 |
| GSE28863_A3 | Up | 0.4989299010 |
| GSE28863_A4 | Up | 0.2144850400 |
| GSE48662 | Down | -0.1575481923 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016330 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028418 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029073 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031541 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26636143 | For correcting alterations in aged epidermis, chemical peelings (fruit acids, beta-hydroxy acid, trichloroacetic acid, phenolic compounds), non-ablative (IPL, PDL, Nd:YAG) as well as ablative (CO2, Erbium-YAG) light-assisted methods are used |
| 24737666 | MATERIALS AND METHODS: Proteomics analysis was performed to identify differentially expressed proteins in human dermal microvascular endothelial cells (HDMEC) treated with ultraviolet (UV) or intense pulsed light (IPL) |
| 24737666 | On the other hand, it was down-regulated after IPL |
| 24737666 | 12) was noted, and this effect was reversed by IPL treatment |
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