HCSGD entry for TSG101
1. General information
| Official gene symbol | TSG101 |
|---|---|
| Entrez ID | 7251 |
| Gene full name | tumor susceptibility gene 101 |
| Other gene symbols | TSG10 VPS23 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000813 | ESCRT I complex | IDA | cellular_component |
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA ISS | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IMP | cellular_component |
| GO:0005771 | Multivesicular body | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006464 | Cellular protein modification process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0010008 | Endosome membrane | TAS | cellular_component |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016197 | Endosomal transport | TAS | biological_process |
| GO:0019068 | Virion assembly | TAS | biological_process |
| GO:0019082 | Viral protein processing | TAS | biological_process |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0031902 | Late endosome membrane | IEA | cellular_component |
| GO:0043130 | Ubiquitin binding | TAS | molecular_function |
| GO:0043162 | Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | IDA IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046755 | Viral budding | IEA IMP ISS | biological_process |
| GO:0048306 | Calcium-dependent protein binding | IPI | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1279303370 | 0.8717808138 | 0.7272687689 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5135408024 |
| GSE13712_SHEAR | Down | -0.4752064464 |
| GSE13712_STATIC | Down | -0.2994974919 |
| GSE19018 | Up | 0.2827364878 |
| GSE19899_A1 | Up | 0.1827120652 |
| GSE19899_A2 | Up | 0.1355279779 |
| PubMed_21979375_A1 | Down | -0.0699559664 |
| PubMed_21979375_A2 | Up | 0.3949276343 |
| GSE35957 | Down | -0.0613715576 |
| GSE36640 | Up | 0.5135851227 |
| GSE54402 | Up | 0.2815103032 |
| GSE9593 | Up | 0.2292614743 |
| GSE43922 | Down | -0.0066038475 |
| GSE24585 | Up | 0.5022043222 |
| GSE37065 | Up | 0.1146838545 |
| GSE28863_A1 | Up | 0.0343202635 |
| GSE28863_A2 | Up | 0.0301854883 |
| GSE28863_A3 | Down | -0.2818132379 |
| GSE28863_A4 | Up | 0.0279700809 |
| GSE48662 | Down | -0.1372114048 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020275 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028151 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028189 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT031083 | Reporter assay | Functional MTI | 21751348 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043363 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26118837 | Here we investigate the gene expression of different target genes related to cell death, namely programmed cell death 4 (PDCD4), tumor susceptibility gene 101 (TSG101), developmental and cell death (DCD) domain, death specific protein (DSP) and metacaspase (MC), using RT-qPCR in the cosmopolitan coastal centric diatom species Skeletonema marinoi, which contributes significantly to phytoplankton blooms in temperate waters |
| 26118837 | On the contrary, PDCD4, DCD, TSG101 and MC did not show any significant variation |
| 18829542 | Ultrastructural analysis and RNA interference-mediated knockdown of Tsg101 provided significant evidence that the additional exosomes released by prematurely senescent prostate cancer cells were principally derived from multivesicular endosomes |
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