HCSGD entry for TRPC1
1. General information
| Official gene symbol | TRPC1 |
|---|---|
| Entrez ID | 7220 |
| Gene full name | transient receptor potential cation channel, subfamily C, member 1 |
| Other gene symbols | HTRP-1 TRP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005261 | Cation channel activity | EXP | molecular_function |
| GO:0005262 | Calcium channel activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006816 | Calcium ion transport | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0015279 | Store-operated calcium channel activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0030017 | Sarcomere | IEA | cellular_component |
| GO:0043034 | Costamere | IEA | cellular_component |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0046541 | Saliva secretion | IEA | biological_process |
| GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | IDA | biological_process |
| GO:0051480 | Cytosolic calcium ion homeostasis | IDA | biological_process |
| GO:0051592 | Response to calcium ion | IDA | biological_process |
| GO:0070679 | Inositol 1,4,5 trisphosphate binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5691911364 | 0.0201165343 | 0.9999902473 | 0.2750905132 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4295702211 |
| GSE13712_SHEAR | Up | 0.2430572828 |
| GSE13712_STATIC | Up | 0.1633603510 |
| GSE19018 | Up | 0.3467699803 |
| GSE19899_A1 | Down | -0.5421540644 |
| GSE19899_A2 | Down | -0.8832192856 |
| PubMed_21979375_A1 | Down | -0.2612679220 |
| PubMed_21979375_A2 | Down | -0.9245691909 |
| GSE35957 | Down | -0.0729854761 |
| GSE36640 | Up | 0.5185393875 |
| GSE54402 | Down | -0.1723011458 |
| GSE9593 | Up | 0.2638946741 |
| GSE43922 | Down | -0.6247268573 |
| GSE24585 | Up | 0.6309662579 |
| GSE37065 | Down | -0.2494267348 |
| GSE28863_A1 | Down | -0.0797787820 |
| GSE28863_A2 | Up | 0.0335982927 |
| GSE28863_A3 | Down | -1.2403343133 |
| GSE28863_A4 | Down | -0.2598401290 |
| GSE48662 | Up | 0.2979244510 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018877 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023057 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024528 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026862 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039618 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11909856 | Hence, raft integrity and store-operated Ca(2+) entry involving transient receptor potential channel 1 channels are essential for completion of the phosphatidylserine transmembrane redistribution process |
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