HCSGD entry for TRIO
1. General information
| Official gene symbol | TRIO |
|---|---|
| Entrez ID | 7204 |
| Gene full name | trio Rho guanine nucleotide exchange factor |
| Other gene symbols | ARHGEF23 tgat |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007185 | Transmembrane receptor protein tyrosine phosphatase signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7313757152 | 0.0463428707 | 0.9999902473 | 0.4040379927 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1269411249 |
| GSE13712_SHEAR | Up | 0.3756612818 |
| GSE13712_STATIC | Up | 0.1932036331 |
| GSE19018 | Down | -0.0323456385 |
| GSE19899_A1 | Down | -0.7978840724 |
| GSE19899_A2 | Down | -0.4337644891 |
| PubMed_21979375_A1 | Down | -1.1558005163 |
| PubMed_21979375_A2 | Down | -0.5011155353 |
| GSE35957 | Up | 0.2805394217 |
| GSE36640 | Down | -0.4176963523 |
| GSE54402 | Down | -0.4705552385 |
| GSE9593 | Up | 0.2572419160 |
| GSE43922 | Down | -0.5919234309 |
| GSE24585 | Down | -0.1463120145 |
| GSE37065 | Down | -0.0598025990 |
| GSE28863_A1 | Up | 0.4374853759 |
| GSE28863_A2 | Up | 0.5741750565 |
| GSE28863_A3 | Up | 0.0737472279 |
| GSE28863_A4 | Down | -0.2635506575 |
| GSE48662 | Down | -0.1036652219 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020707 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028297 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028514 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038821 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052599 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
