HCSGD entry for TRAF2

1. General information

Official gene symbol	TRAF2
Entrez ID	7186
Gene full name	TNF receptor-associated factor 2
Other gene symbols	MGC:45012 TRAP TRAP3
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0002726	Positive regulation of T cell cytokine production	IMP	biological_process
GO:0004842	Ubiquitin-protein ligase activity	IDA IEA	molecular_function
GO:0004871	Signal transducer activity	NAS	molecular_function
GO:0005164	Tumor necrosis factor receptor binding	IPI	molecular_function
GO:0005174	CD40 receptor binding	IEA ISS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005829	Cytosol	TAS	cellular_component
GO:0005938	Cell cortex	IEA	cellular_component
GO:0006461	Protein complex assembly	TAS	biological_process
GO:0006915	Apoptotic process	TAS	biological_process
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	biological_process
GO:0007165	Signal transduction	TAS	biological_process
GO:0007250	Activation of NF-kappaB-inducing kinase activity	IEA IMP	biological_process
GO:0008270	Zinc ion binding	IEA	molecular_function
GO:0009898	Cytoplasmic side of plasma membrane	IEA ISS	cellular_component
GO:0019899	Enzyme binding	IPI	molecular_function
GO:0019903	Protein phosphatase binding	IPI	molecular_function
GO:0030163	Protein catabolic process	IEA	biological_process
GO:0031435	Mitogen-activated protein kinase kinase kinase binding	IEA	molecular_function
GO:0031625	Ubiquitin protein ligase binding	IPI	molecular_function
GO:0031996	Thioesterase binding	IPI	molecular_function
GO:0032403	Protein complex binding	IEA	molecular_function
GO:0032743	Positive regulation of interleukin-2 production	IMP	biological_process
GO:0033209	Tumor necrosis factor-mediated signaling pathway	IDA IEA	biological_process
GO:0034351	Negative regulation of glial cell apoptotic process	IEA	biological_process
GO:0035631	CD40 receptor complex	IEA ISS	cellular_component
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0042981	Regulation of apoptotic process	IDA IEA	biological_process
GO:0043507	Positive regulation of JUN kinase activity	IDA	biological_process
GO:0043623	Cellular protein complex assembly	IEA ISS	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0045121	Membrane raft	IEA	cellular_component
GO:0046328	Regulation of JNK cascade	IEA	biological_process
GO:0046625	Sphingolipid binding	IDA	molecular_function
GO:0050870	Positive regulation of T cell activation	IC	biological_process
GO:0051023	Regulation of immunoglobulin secretion	IEA	biological_process
GO:0051091	Positive regulation of sequence-specific DNA binding transcription factor activity	IMP	biological_process
GO:0051092	Positive regulation of NF-kappaB transcription factor activity	IDA IEA IMP	biological_process
GO:0051291	Protein heterooligomerization	IEA	biological_process
GO:0051865	Protein autoubiquitination	IDA IEA TAS	biological_process
GO:0070207	Protein homotrimerization	IPI	biological_process
GO:0070534	Protein K63-linked ubiquitination	IDA	biological_process
GO:0090073	Positive regulation of protein homodimerization activity	IMP	biological_process
GO:0097190	Apoptotic signaling pathway	TAS	biological_process
GO:2001238	Positive regulation of extrinsic apoptotic signaling pathway	IMP	biological_process
GO:2001239	Regulation of extrinsic apoptotic signaling pathway in absence of ligand	TAS	biological_process

Entries Per Page

Displaying Page of

4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.8461513810	0.2345354014	0.9999902473	0.9327427730

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1044070203
GSE13712_SHEAR	Up	0.1375225299
GSE13712_STATIC	Up	0.3067686051
GSE19018	Up	0.1717334335
GSE19899_A1	Down	-0.1860209859
GSE19899_A2	Down	-0.0586065407
PubMed_21979375_A1	Down	-0.3131856409
PubMed_21979375_A2	Down	-0.2212938209
GSE35957	Down	-0.4635833648
GSE36640	Down	-0.1818254701
GSE54402	Down	-0.0393579874
GSE9593	Down	-0.3086379950
GSE43922	Up	0.1059038849
GSE24585	Down	-0.4366732677
GSE37065	Up	0.0849753657
GSE28863_A1	Down	-0.1347463662
GSE28863_A2	Down	-0.0338501796
GSE28863_A3	Up	0.2033489785
GSE28863_A4	Up	0.1897869673
GSE48662	Down	-0.0546457168

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results