HCSGD entry for TRAF1
1. General information
| Official gene symbol | TRAF1 |
|---|---|
| Entrez ID | 7185 |
| Gene full name | TNF receptor-associated factor 1 |
| Other gene symbols | EBI6 MGC:10353 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0031996 | Thioesterase binding | IPI | molecular_function |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | RCA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:2001236 | Regulation of extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1416604080 | 0.6701121234 | 0.7561061220 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0676026140 |
| GSE13712_SHEAR | Up | 1.0052511954 |
| GSE13712_STATIC | Up | 1.0283868080 |
| GSE19018 | Up | 0.0451540952 |
| GSE19899_A1 | Up | 0.0841940102 |
| GSE19899_A2 | Up | 0.1584852437 |
| PubMed_21979375_A1 | Down | -0.0961132781 |
| PubMed_21979375_A2 | Up | 0.0319612663 |
| GSE35957 | Down | -0.5977724081 |
| GSE36640 | Down | -0.2890715648 |
| GSE54402 | Up | 0.4577897936 |
| GSE9593 | Down | -0.1765153722 |
| GSE43922 | Down | -0.0158299841 |
| GSE24585 | Up | 0.3630059099 |
| GSE37065 | Down | -0.0041699887 |
| GSE28863_A1 | Down | -0.1123771581 |
| GSE28863_A2 | Down | -0.2125871594 |
| GSE28863_A3 | Up | 0.0115786696 |
| GSE28863_A4 | Up | 0.0297171175 |
| GSE48662 | Up | 0.1419112613 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027456 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028837 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043860 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
