HCSGD entry for C3

1. General information

Official gene symbolC3
Entrez ID718
Gene full namecomplement component 3
Other gene symbolsAHUS5 ARMD9 ASP C3a C3b CPAMD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001798Positive regulation of type IIa hypersensitivityIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0001970Positive regulation of activation of membrane attack complexIEAbiological_process
GO:0004866Endopeptidase inhibitor activityIEAmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0006956Complement activationIEA TASbiological_process
GO:0006957Complement activation, alternative pathwayTASbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIDAbiological_process
GO:0010828Positive regulation of glucose transportIDAbiological_process
GO:0010866Regulation of triglyceride biosynthetic processIDAbiological_process
GO:0010884Positive regulation of lipid storageIDAbiological_process
GO:0030449Regulation of complement activationTASbiological_process
GO:0031715C5L2 anaphylatoxin chemotactic receptor bindingIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045745Positive regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0050766Positive regulation of phagocytosisIEAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00000741230.98735704190.01157777781.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8801832908
GSE13712_SHEARUp0.6740447670
GSE13712_STATICUp0.7839129819
GSE19018Up0.0077817768
GSE19899_A1Up0.5650477489
GSE19899_A2Up5.1991916912
PubMed_21979375_A1Up6.0425193454
PubMed_21979375_A2Up3.8744186681
GSE35957Up1.3650932577
GSE36640Up4.3193565135
GSE54402Up0.0967290011
GSE9593Down-0.9321180781
GSE43922Up3.7829542245
GSE24585Up0.3704356170
GSE37065Up1.1012267839
GSE28863_A1Up3.1804933388
GSE28863_A2Up1.9160051588
GSE28863_A3Up0.4263125316
GSE28863_A4Down-0.1086831186
GSE48662Up0.0823028041

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Immune Globulin HumanDB00028 BTD00091 | BIOD00091
S-HydroxycysteineDB01915 EXPT01035 | DB03398

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027814MicroarrayFunctional MTI (Weak)19088304
hsa-miR-26b-5pMIMAT0000083MIRT030181MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.