HCSGD entry for TPR

1. General information

Official gene symbolTPR
Entrez ID7175
Gene full nametranslocated promoter region, nuclear basket protein
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000189MAPK import into nucleusIMPbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003729MRNA bindingIDAmolecular_function
GO:0004828Serine-tRNA ligase activityIEAmolecular_function
GO:0005215Transporter activityIMPmolecular_function
GO:0005487Nucleocytoplasmic transporter activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIDAcellular_component
GO:0005643Nuclear poreIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005868Cytoplasmic dynein complexIDAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006404RNA import into nucleusIDAbiological_process
GO:0006405RNA export from nucleusIMPbiological_process
GO:0006434Seryl-tRNA aminoacylationIEAbiological_process
GO:0006606Protein import into nucleusIDA IMPbiological_process
GO:0006611Protein export from nucleusIMPbiological_process
GO:0006999Nuclear pore organizationIMPbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007077Mitotic nuclear envelope disassemblyTASbiological_process
GO:0007094Mitotic spindle assembly checkpointIMPbiological_process
GO:0008645Hexose transportTASbiological_process
GO:0010793Regulation of mRNA export from nucleusIMPbiological_process
GO:0010827Regulation of glucose transportTASbiological_process
GO:0010965Regulation of mitotic sister chromatid separationIMPbiological_process
GO:0015631Tubulin bindingIDAmolecular_function
GO:0015758Glucose transportTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019898Extrinsic component of membraneIDAcellular_component
GO:0031072Heat shock protein bindingIDAmolecular_function
GO:0031453Positive regulation of heterochromatin assemblyIMPbiological_process
GO:0031647Regulation of protein stabilityIMPbiological_process
GO:0031965Nuclear membraneIDAcellular_component
GO:0031990MRNA export from nucleus in response to heat stressIDAbiological_process
GO:0034399Nuclear peripheryIDAcellular_component
GO:0034605Cellular response to heatIDAbiological_process
GO:0035457Cellular response to interferon-alphaISSbiological_process
GO:0042306Regulation of protein import into nucleusIMPbiological_process
GO:0042307Positive regulation of protein import into nucleusIMPbiological_process
GO:0042405Nuclear inclusion bodyIDAcellular_component
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043495Protein anchorIMPmolecular_function
GO:0043578Nuclear matrix organizationIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044615Nuclear pore nuclear basketIDAcellular_component
GO:0045947Negative regulation of translational initiationIMPbiological_process
GO:0046825Regulation of protein export from nucleusIMPbiological_process
GO:0046827Positive regulation of protein export from nucleusISSbiological_process
GO:0046832Negative regulation of RNA export from nucleusIDA IMPbiological_process
GO:0051019Mitogen-activated protein kinase bindingIDAmolecular_function
GO:0051292Nuclear pore complex assemblyIMPbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070840Dynein complex bindingIDAmolecular_function
GO:0070849Response to epidermal growth factorIDAbiological_process
GO:0072686Mitotic spindleIDAcellular_component
GO:0090267Positive regulation of mitotic cell cycle spindle assembly checkpointIMPbiological_process
GO:0090316Positive regulation of intracellular protein transportIMPbiological_process
GO:1901673Regulation of spindle assembly involved in mitosisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25575703430.12204175750.94781996340.6700586358

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1768053444
GSE13712_SHEARDown-0.1600576445
GSE13712_STATICDown-0.1317812155
GSE19018Down-0.1530080859
GSE19899_A1Down-0.0768281379
GSE19899_A2Down-0.9647455153
PubMed_21979375_A1Down-0.3819124151
PubMed_21979375_A2Down-0.0691872071
GSE35957Down-0.1516644696
GSE36640Down-0.5585579844
GSE54402Down-0.1405599793
GSE9593Up0.1265030213
GSE43922Down-0.1464897635
GSE24585Up0.2048999311
GSE37065Down-0.0247900041
GSE28863_A1Up1.3252440472
GSE28863_A2Up1.6056295783
GSE28863_A3Down-0.0407610171
GSE28863_A4Down-0.0995047142
GSE48662Down-0.0551486516

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020054MicroarrayFunctional MTI (Weak)20215506
hsa-miR-1180-3pMIMAT0005825MIRT035929CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040002CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-5pMIMAT0000731MIRT043991CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21811608Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells
21811608BACKGROUND: Tpr is a large coiled-coil protein located in the nuclear basket of the nuclear pore complex for which many different functions were proposed from yeast to human
21811608METHODOLOGY/PRINCIPAL FINDINGS: Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately induces a senescent-like phenotype dependent on the presence of p53
21811608We also found that Tpr depletion impairs the NES [nuclear export sequence]-dependent nuclear export of proteins and causes partial co-depletion of Nup153
21811608In addition Tpr depletion impacts on level and function of the SUMO-protease SENP2 thus affecting SUMOylation regulation at the nuclear pore and overall SUMOylation in the cell
21811608Our findings also point to new roles for Tpr in the regulation of SUMO-1 conjugation at the nuclear pore and directly confirm Tpr involvement in the nuclear export of NES-proteins
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