HCSGD entry for TPP2
1. General information
| Official gene symbol | TPP2 |
|---|---|
| Entrez ID | 7174 |
| Gene full name | tripeptidyl peptidase II |
| Other gene symbols | TPP-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | TAS | biological_process |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0004175 | Endopeptidase activity | TAS | molecular_function |
| GO:0004177 | Aminopeptidase activity | IEA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IBA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IBA IEA | biological_process |
| GO:0008240 | Tripeptidyl-peptidase activity | IEA | molecular_function |
| GO:0042277 | Peptide binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6968114737 | 0.3671031876 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1073948008 |
| GSE13712_SHEAR | Down | -0.3020665640 |
| GSE13712_STATIC | Down | -0.2589177463 |
| GSE19018 | Down | -0.2280454649 |
| GSE19899_A1 | Up | 0.0776268765 |
| GSE19899_A2 | Down | -0.0447892318 |
| PubMed_21979375_A1 | Up | 0.0380736331 |
| PubMed_21979375_A2 | Up | 0.1468415415 |
| GSE35957 | Down | -0.2431287228 |
| GSE36640 | Down | -0.2866710877 |
| GSE54402 | Up | 0.5710135384 |
| GSE9593 | Up | 0.0434739536 |
| GSE43922 | Down | -0.0390546236 |
| GSE24585 | Down | -0.1069990757 |
| GSE37065 | Down | -0.0233140084 |
| GSE28863_A1 | Up | 0.1565468331 |
| GSE28863_A2 | Up | 0.1012580878 |
| GSE28863_A3 | Down | -0.5040920322 |
| GSE28863_A4 | Up | 0.1739489620 |
| GSE48662 | Down | -0.0711673355 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020939 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032480 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18362329 | The giant cytosolic protease tripeptidyl peptidase II (TPPII) has been implicated in the regulation of proliferation and survival of malignant cells, particularly lymphoma cells |
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