HCSGD entry for TPO
1. General information
| Official gene symbol | TPO |
|---|---|
| Entrez ID | 7173 |
| Gene full name | thyroid peroxidase |
| Other gene symbols | MSA TDH2A TPX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004447 | Iodide peroxidase activity | IEA | molecular_function |
| GO:0004601 | Peroxidase activity | IEA TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006590 | Thyroid hormone generation | IEA TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0035162 | Embryonic hemopoiesis | IDA | biological_process |
| GO:0042446 | Hormone biosynthetic process | IEA | biological_process |
| GO:0042744 | Hydrogen peroxide catabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8189694958 | 0.5861613237 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0245103110 |
| GSE13712_SHEAR | Down | -0.0232404555 |
| GSE13712_STATIC | Down | -0.2389610760 |
| GSE19018 | Down | -0.1054079902 |
| GSE19899_A1 | Up | 0.1772766243 |
| GSE19899_A2 | Down | -0.1046042322 |
| PubMed_21979375_A1 | Down | -0.4742865659 |
| PubMed_21979375_A2 | Down | -0.2168796036 |
| GSE35957 | Up | 0.0595537786 |
| GSE36640 | Down | -0.0147924771 |
| GSE54402 | Up | 0.0342012880 |
| GSE9593 | Down | -0.0614520127 |
| GSE43922 | Up | 0.0132977262 |
| GSE24585 | Down | -0.0762958849 |
| GSE37065 | Up | 0.0108843805 |
| GSE28863_A1 | Down | -0.0533634309 |
| GSE28863_A2 | Up | 0.0612653864 |
| GSE28863_A3 | Up | 0.2305269782 |
| GSE28863_A4 | Up | 0.1561148063 |
| GSE48662 | Up | 0.1413731290 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018757 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030038 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18491948 | Recently, we reported extensive expansion without cell senescence of cord blood (CB)-derived HSC cocultured with OP9 stromal cells for more than 18 weeks with a single cytokine support using human thrombopoietin (TPO) |
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