HCSGD entry for TPM1
1. General information
| Official gene symbol | TPM1 |
|---|---|
| Entrez ID | 7168 |
| Gene full name | tropomyosin 1 (alpha) |
| Other gene symbols | C15orf13 CMD1Y CMH3 HTM-alpha TMSA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0003065 | Positive regulation of heart rate by epinephrine | IEA ISS | biological_process |
| GO:0003779 | Actin binding | TAS | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005862 | Muscle thin filament tropomyosin | TAS | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0006937 | Regulation of muscle contraction | TAS | biological_process |
| GO:0007010 | Cytoskeleton organization | TAS | biological_process |
| GO:0008016 | Regulation of heart contraction | TAS | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IPI | molecular_function |
| GO:0008307 | Structural constituent of muscle | TAS | molecular_function |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0030016 | Myofibril | IEA | cellular_component |
| GO:0030017 | Sarcomere | TAS | cellular_component |
| GO:0030049 | Muscle filament sliding | ISS TAS | biological_process |
| GO:0030336 | Negative regulation of cell migration | ISS | biological_process |
| GO:0031529 | Ruffle organization | ISS | biological_process |
| GO:0031941 | Filamentous actin | IEA | cellular_component |
| GO:0032059 | Bleb | IMP | cellular_component |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0032781 | Positive regulation of ATPase activity | ISS | biological_process |
| GO:0034614 | Cellular response to reactive oxygen species | IEP | biological_process |
| GO:0042060 | Wound healing | ISS | biological_process |
| GO:0045214 | Sarcomere organization | IMP | biological_process |
| GO:0045785 | Positive regulation of cell adhesion | ISS | biological_process |
| GO:0051496 | Positive regulation of stress fiber assembly | ISS | biological_process |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IEA IMP | biological_process |
| GO:0060048 | Cardiac muscle contraction | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9915730025 | 0.0004377417 | 0.9999902473 | 0.0387127517 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8995069505 |
| GSE13712_SHEAR | Down | -0.0143114860 |
| GSE13712_STATIC | Up | 0.0370600946 |
| GSE19018 | Down | -0.2865535160 |
| GSE19899_A1 | Down | -0.7187711676 |
| GSE19899_A2 | Down | -1.3095132251 |
| PubMed_21979375_A1 | Down | -2.8578369184 |
| PubMed_21979375_A2 | Down | -1.4991566238 |
| GSE35957 | Up | 0.0324454859 |
| GSE36640 | Up | 0.4484197490 |
| GSE54402 | Down | -0.8278759088 |
| GSE9593 | Down | -0.0460489482 |
| GSE43922 | Down | -0.6212636618 |
| GSE24585 | Down | -0.4627901923 |
| GSE37065 | Down | -0.4509266282 |
| GSE28863_A1 | Down | -0.9970227691 |
| GSE28863_A2 | Down | -0.7414923594 |
| GSE28863_A3 | Down | -0.0922056846 |
| GSE28863_A4 | Down | -0.0571268868 |
| GSE48662 | Down | -0.3008304926 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001327 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001327 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001980 | Luciferase reporter assay | Functional MTI | 18270520 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001980 | Luciferase reporter assay//Western blot;qRT-PCR | Functional MTI | 17363372 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001980 | Luciferase reporter assay | Functional MTI | 19253296 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001980 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT021693 | Microarray | Functional MTI (Weak) | 21396852 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023135 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025560 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {underexpression by anti-miRNA oligonucleotides} | 17363372 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7796463 | To shed light on the relationship between functions of the cytoskeleton and senescence or immortalization, we investigated the alterations in gene expression after immortalization and measured the amounts of mRNAs for talin, vinculin, alpha-actinin, tropomyosin 1 (TM1), vimentin, lamin A and C, and alpha-tubulin by slot blot and Northern blot analyses |
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