HCSGD entry for TP73

1. General information

Official gene symbolTP73
Entrez ID7161
Gene full nametumor protein p73
Other gene symbolsP73
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0000785ChromatinIBAcellular_component
GO:0001822Kidney developmentIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIEAbiological_process
GO:0002039P53 bindingIBAmolecular_function
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003684Damaged DNA bindingIBAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0005829CytosolIBAcellular_component
GO:0006298Mismatch repairTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIBAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageTASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010165Response to X-rayIBAbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010332Response to gamma radiationIBAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021766Hippocampus developmentIEAbiological_process
GO:0031571Mitotic G1 DNA damage checkpointIBAbiological_process
GO:0033326Cerebrospinal fluid secretionIEAbiological_process
GO:0034644Cellular response to UVIBAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIBA IDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043508Negative regulation of JUN kinase activityIBAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIBAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDA IEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045793Positive regulation of cell sizeIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0051262Protein tetramerizationIEAbiological_process
GO:1902167Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26501209300.97249342730.95988981701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0175407874
GSE13712_SHEARUp0.0586407707
GSE13712_STATICUp0.0521756336
GSE19018Up0.0930256930
GSE19899_A1Up0.0199157686
GSE19899_A2Up0.1481502043
PubMed_21979375_A1Up0.2233507560
PubMed_21979375_A2Up0.0000606564
GSE35957Up0.0792493953
GSE36640Up0.0119761855
GSE54402Up0.0103141440
GSE9593Down-0.0234645063
GSE43922Up0.1626031177
GSE24585Up0.2146109104
GSE37065Down-0.0040852901
GSE28863_A1Down-0.0519204003
GSE28863_A2Up0.0604036251
GSE28863_A3Up0.3997939370
GSE28863_A4Up0.1245467956
GSE48662Up0.3124457212

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193a-5pMIMAT0004614MIRT005603Immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21293058
hsa-miR-205-5pMIMAT0000266MIRT006897qRT-PCR//Western blotFunctional MTI22871739
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.