HCSGD entry for C1S
1. General information
| Official gene symbol | C1S |
|---|---|
| Entrez ID | 716 |
| Gene full name | complement component 1, s subcomponent |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006956 | Complement activation | TAS | biological_process |
| GO:0006958 | Complement activation, classical pathway | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0617217431 | 0.0011512822 | 0.5383702121 | 0.0644742553 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4534649263 |
| GSE13712_SHEAR | Down | -0.0648237292 |
| GSE13712_STATIC | Up | 0.2881951464 |
| GSE19018 | Down | -1.2598067966 |
| GSE19899_A1 | Down | -1.8265124504 |
| GSE19899_A2 | Down | -3.0849187862 |
| PubMed_21979375_A1 | Down | -3.1441896653 |
| PubMed_21979375_A2 | Down | -4.8438846383 |
| GSE35957 | Up | 0.3080353896 |
| GSE36640 | Up | 1.8274994537 |
| GSE54402 | Down | -2.0531399057 |
| GSE9593 | Up | 0.9137711695 |
| GSE43922 | Down | -1.4928451279 |
| GSE24585 | Up | 0.9118396291 |
| GSE37065 | Up | 0.2828546750 |
| GSE28863_A1 | Up | 0.5921428714 |
| GSE28863_A2 | Up | 0.8042967161 |
| GSE28863_A3 | Down | -0.0940603834 |
| GSE28863_A4 | Up | 0.0026293372 |
| GSE48662 | Up | 0.2186627326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cetuximab | DB00002 | BTD00071 | BIOD00071 |
| Etanercept | DB00005 | BTD00052 | BIOD00052 |
| Adalimumab | DB00051 | BTD00049 | BIOD00049 |
| Abciximab | DB00054 | BTD00041 | BIOD00041 |
| Gemtuzumab ozogamicin | DB00056 | BTD00077 | BIOD00077 |
| Trastuzumab | DB00072 | BTD00098 | BIOD00098 |
| Rituximab | DB00073 | BTD00014 | BIOD00014 |
| Basiliximab | DB00074 | BTD00073 | BIOD00073 |
| Muromonab | DB00075 | BTD00005 | BIOD00005 |
| Ibritumomab tiuxetan | DB00078 | BTD00069 | BIOD00069 |
| 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid | DB02371 | EXPT02328 |
| C1 Esterase Inhibitor (Recombinant) | DB09228 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018885 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
