HCSGD entry for TP53BP2
1. General information
| Official gene symbol | TP53BP2 |
|---|---|
| Entrez ID | 7159 |
| Gene full name | tumor protein p53 binding protein, 2 |
| Other gene symbols | 53BP2 ASPP2 BBP P53BP2 PPP1R13A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0009792 | Embryo development ending in birth or egg hatching | IEA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0010212 | Response to ionizing radiation | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045786 | Negative regulation of cell cycle | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4476176323 | 0.1031022378 | 0.9999902473 | 0.6150996827 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3556242593 |
| GSE13712_SHEAR | Down | -0.3157243998 |
| GSE13712_STATIC | Down | -0.0418263098 |
| GSE19018 | Down | -0.1098587692 |
| GSE19899_A1 | Down | -0.5157114887 |
| GSE19899_A2 | Up | 0.1708617628 |
| PubMed_21979375_A1 | Up | 0.4293586873 |
| PubMed_21979375_A2 | Down | -0.0867248703 |
| GSE35957 | Up | 0.1713176891 |
| GSE36640 | Down | -0.7662468824 |
| GSE54402 | Up | 0.3440140540 |
| GSE9593 | Up | 0.2107040923 |
| GSE43922 | Down | -0.1602726725 |
| GSE24585 | Up | 0.1776263979 |
| GSE37065 | Up | 0.2264587875 |
| GSE28863_A1 | Up | 0.4888653386 |
| GSE28863_A2 | Up | 0.7127159311 |
| GSE28863_A3 | Down | -0.2081588675 |
| GSE28863_A4 | Down | -0.3520060981 |
| GSE48662 | Down | -0.5221052476 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT005328 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18829576 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036049 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036878 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23392125 | ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells |
| 23392125 | Additionally, ASPP2 colocalises with and contributes to RAS cellular membrane localisation and potentiates RAS signalling |
| 23392125 | In cancer cells, ASPP1 and ASPP2 cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 |
| 23392125 | Thus, loss of ASPP1 and ASPP2 in human cancer cells may contribute to the full transforming property of RAS oncogene |
| 22917970 | Structural basis for ASPP2 recognition by the tumor suppressor p73 |
| 22917970 | To further understand the variant features of p73, we solved the high-resolution crystal structure of the p73 DBD as well as its complex with the ankyrin repeat and SH3 domains of the pro-apoptotic factor ASPP2 |
| 22917970 | Importantly, the binding of ASPP2 is preserved by conformational changes in both the ankyrin repeat and SH3 domains |
Entries Per Page
Displaying Page of
