HCSGD entry for TOP3A
1. General information
| Official gene symbol | TOP3A |
|---|---|
| Entrez ID | 7156 |
| Gene full name | topoisomerase (DNA) III alpha |
| Other gene symbols | TOP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003917 | DNA topoisomerase type I activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006265 | DNA topological change | IDA IEA | biological_process |
| GO:0007126 | Meiosis | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2161399985 | 0.7862861062 | 0.8952039182 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1281640627 |
| GSE13712_SHEAR | Up | 0.3275883983 |
| GSE13712_STATIC | Up | 0.1268686976 |
| GSE19018 | Down | -0.1185196697 |
| GSE19899_A1 | Down | -0.0388413002 |
| GSE19899_A2 | Down | -0.2901633718 |
| PubMed_21979375_A1 | Up | 0.4278449119 |
| PubMed_21979375_A2 | Up | 0.1199361801 |
| GSE35957 | Down | -0.2382637457 |
| GSE36640 | Down | -0.7601743841 |
| GSE54402 | Up | 0.2172728168 |
| GSE9593 | Down | -0.0270462156 |
| GSE43922 | Up | 0.3133616097 |
| GSE24585 | Up | 0.1626922408 |
| GSE37065 | Down | -0.0596759005 |
| GSE28863_A1 | Up | 0.6748735122 |
| GSE28863_A2 | Up | 0.2096218813 |
| GSE28863_A3 | Down | -0.1157682853 |
| GSE28863_A4 | Down | -0.0324724386 |
| GSE48662 | Up | 0.1008655486 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320a | MIMAT0000510 | MIRT044415 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046639 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
