HCSGD entry for TOP2B
1. General information
| Official gene symbol | TOP2B |
|---|---|
| Entrez ID | 7155 |
| Gene full name | topoisomerase (DNA) II beta 180kDa |
| Other gene symbols | TOPIIB top2beta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000712 | Resolution of meiotic recombination intermediates | IBA | biological_process |
| GO:0000792 | Heterochromatin | IDA | cellular_component |
| GO:0000795 | Synaptonemal complex | IBA | cellular_component |
| GO:0000819 | Sister chromatid segregation | IBA | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IBA IDA IEA | molecular_function |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IBA IDA | biological_process |
| GO:0006261 | DNA-dependent DNA replication | IBA | biological_process |
| GO:0006265 | DNA topological change | IBA IDA IEA | biological_process |
| GO:0006312 | Mitotic recombination | IBA | biological_process |
| GO:0007059 | Chromosome segregation | IBA | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008301 | DNA binding, bending | IEA | molecular_function |
| GO:0009295 | Nucleoid | IBA | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0071778 | WINAC complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9072759318 | 0.0064096311 | 0.9999902473 | 0.1630028019 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3333784003 |
| GSE13712_SHEAR | Down | -0.0173272518 |
| GSE13712_STATIC | Down | -0.0008079510 |
| GSE19018 | Up | 0.2263007514 |
| GSE19899_A1 | Down | -1.0157039351 |
| GSE19899_A2 | Down | -0.6896308817 |
| PubMed_21979375_A1 | Down | -0.8961016778 |
| PubMed_21979375_A2 | Down | -0.8193063241 |
| GSE35957 | Down | -0.0635257221 |
| GSE36640 | Down | -0.6494453467 |
| GSE54402 | Down | -0.2576235082 |
| GSE9593 | Down | -0.7425814262 |
| GSE43922 | Down | -0.6996683614 |
| GSE24585 | Down | -0.5151595857 |
| GSE37065 | Down | -0.2201676888 |
| GSE28863_A1 | Up | 1.1514126797 |
| GSE28863_A2 | Up | 0.9250621483 |
| GSE28863_A3 | Down | -0.2526874506 |
| GSE28863_A4 | Down | -0.1828405850 |
| GSE48662 | Down | -0.3562088949 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dexrazoxane | DB00380 | APRD00090 | DB02444 |
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
| Amonafide | DB05022 | - |
| 99mTc-ciprofloxacin | DB05488 | - |
| ZEN-012 | DB06042 | - |
| 3'-THIO-THYMIDINE-5'-PHOSPHATE | DB08651 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029687 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
