HCSGD entry for TOP1
1. General information
| Official gene symbol | TOP1 |
|---|---|
| Entrez ID | 7150 |
| Gene full name | topoisomerase (DNA) I |
| Other gene symbols | TOPI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IDA | cellular_component |
| GO:0000932 | Cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003917 | DNA topoisomerase type I activity | IDA IMP | molecular_function |
| GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006260 | DNA replication | IBA | biological_process |
| GO:0006265 | DNA topological change | IBA IDA | biological_process |
| GO:0006338 | Chromatin remodeling | IBA | biological_process |
| GO:0007059 | Chromosome segregation | IBA | biological_process |
| GO:0012501 | Programmed cell death | NAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016310 | Phosphorylation | NAS | biological_process |
| GO:0031298 | Replication fork protection complex | IBA | cellular_component |
| GO:0040016 | Embryonic cleavage | IEA | biological_process |
| GO:0042493 | Response to drug | IEP | biological_process |
| GO:0043204 | Perikaryon | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0633287109 | 0.4804729570 | 0.5429963867 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6535166576 |
| GSE13712_SHEAR | Up | 0.2478179870 |
| GSE13712_STATIC | Up | 0.0461452215 |
| GSE19018 | Down | -0.9803705730 |
| GSE19899_A1 | Up | 0.9453783760 |
| GSE19899_A2 | Up | 0.4721793408 |
| PubMed_21979375_A1 | Up | 0.8165240363 |
| PubMed_21979375_A2 | Up | 0.5788520713 |
| GSE35957 | Down | -1.0216154421 |
| GSE36640 | Down | -0.3076560506 |
| GSE54402 | Up | 0.3768138403 |
| GSE9593 | Up | 0.0330065810 |
| GSE43922 | Up | 0.3451137956 |
| GSE24585 | Down | -0.1677834581 |
| GSE37065 | Up | 0.1378293371 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2651848832 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Irinotecan | DB00762 | APRD00579 |
| Topotecan | DB01030 | APRD00687 |
| Camptothecin | DB04690 | - |
| Edotecarin | DB04882 | - |
| Lucanthone | DB04967 | - |
| Elsamitrucin | DB05129 | - |
| LE-SN38 | DB05482 | - |
| BNP 1350 | DB05806 | - |
| XMT-1001 | DB06069 | - |
| 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM | DB07354 | - |
| 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE | DB08159 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024385 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026200 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028857 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030382 | qRT-PCR;Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-484 | MIMAT0002174 | MIRT042230 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044929 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26959889 | In a large clinical cohort of breast cancer patients, we find that WRN and topoisomerase I expression correlate with an aggressive tumor phenotype and poor prognosis |
| 26748253 | DNA topoisomerase I (TOP1), an enzyme controlling DNA topology, was identified as a target of mir-24, whose expression was induced by oxidative stress |
| 26748253 | These results suggest that mir-24 activity propagates stress-induced senescence by down regulating TOP1 |
| 24473175 | These include nuclear topoisomerase I, relevant kinases (such as cyclin-dependent kinase 2) and the mitochondrial electron transport chain |
| 24473175 | The onset of cellular senescence is dependent on the presence of intact topoisomerase I since topoisomerase I-mutated cells are resistant to senescence induced by LamD |
| 23137030 | Also reviewed are its applications to detect and explore mechanisms of DDS induced by variety of exogenous agents targeting DNA such as exogenous oxidants, ionizing radiation, radiomimetic drugs, UV light, DNA topoisomerase I and II inhibitors, DNA crosslinking drugs and variety of environmental genotoxins |
| 10811146 | CBFA1 and topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts |
| 10811146 | In addition, the expression of topoisomerase I is reduced by 40% in senescent osteoblasts, and the mRNA levels are significantly higher (40-70%) in transformed osteoblasts and fibroblasts |
| 10227381 | The activity of these extracts was compared after supplementation with three recombinant human replication factors: (1) the catalytic subunit of DNA polymerase alpha (DNA pol-alpha-cat), (2) the three subunits of replication protein A (RPA), and (3) DNA topoisomerase I (Topo I) |
| 9042398 | Downregulation of DNA topoisomerase I in old versus young human diploid fibroblasts |
| 9042398 | DNA topoisomerase I (Topo I) is an enzyme that alters the superhelicity of DNA |
| 7937091 | The topoisomerase I gene from Ustilago maydis: sequence, disruption and mutant phenotype |
| 7937091 | The Ustilago maydis genomic TOP1 gene encoding DNA topoisomerase I was cloned by amplifying a gene fragment using the polymerase chain reaction, and using this fragment to search a genomic DNA library by hybridization |
| 7937091 | The predicted peptide sequence exhibited 30-40% identity to other eukaryotic TOP1 genes, yet differed in several features |
| 7937091 | Second, an atypical carboxy-terminal 'tail', absent in other TOP1 genes, followed the active site tyrosine residue |
| 7937091 | A top1 gene disruption mutant was constructed by replacing the genomic TOP1 gene, with a top1::HygR null allele |
| 7937091 | This mutant lost the abundant topoisomerase I activity evident in wild-type U |
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