HCSGD entry for C1R
1. General information
| Official gene symbol | C1R |
|---|---|
| Entrez ID | 715 |
| Gene full name | complement component 1, r subcomponent |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | EXP IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0006956 | Complement activation | IEA TAS | biological_process |
| GO:0006958 | Complement activation, classical pathway | TAS | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7103392234 | 0.0000631549 | 0.9999902473 | 0.0130889764 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.7668624812 |
| GSE13712_SHEAR | Down | -0.9399222859 |
| GSE13712_STATIC | Down | -0.0451939057 |
| GSE19018 | Down | -2.0947279090 |
| GSE19899_A1 | Down | -2.1182256756 |
| GSE19899_A2 | Down | -5.9977914229 |
| PubMed_21979375_A1 | Down | -4.3153185309 |
| PubMed_21979375_A2 | Down | -4.6833791498 |
| GSE35957 | Down | -0.4945688771 |
| GSE36640 | Up | 0.1568054355 |
| GSE54402 | Down | -2.4896822372 |
| GSE9593 | Down | -0.6593345983 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 1.0064999519 |
| GSE28863_A2 | Up | 1.0042736239 |
| GSE28863_A3 | Up | 0.1637969627 |
| GSE28863_A4 | Down | -0.0975491139 |
| GSE48662 | Up | 0.2384248814 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cetuximab | DB00002 | BTD00071 | BIOD00071 |
| Etanercept | DB00005 | BTD00052 | BIOD00052 |
| Adalimumab | DB00051 | BTD00049 | BIOD00049 |
| Abciximab | DB00054 | BTD00041 | BIOD00041 |
| Gemtuzumab ozogamicin | DB00056 | BTD00077 | BIOD00077 |
| Trastuzumab | DB00072 | BTD00098 | BIOD00098 |
| Rituximab | DB00073 | BTD00014 | BIOD00014 |
| Basiliximab | DB00074 | BTD00073 | BIOD00073 |
| Muromonab | DB00075 | BTD00005 | BIOD00005 |
| Ibritumomab tiuxetan | DB00078 | BTD00069 | BIOD00069 |
| Tositumomab | DB00081 | BTD00085 | BIOD00085 |
| Alemtuzumab | DB00087 | BTD00109 | BIOD00109 |
| Alefacept | DB00092 | BTD00055 | BIOD00055 |
| Efalizumab | DB00095 | BTD00074 | BIOD00074 |
| Natalizumab | DB00108 | BTD00083 | BIOD00083 |
| Palivizumab | DB00110 | BTD00097 | BIOD00097 |
| Daclizumab | DB00111 | BTD00007 | BIOD00007 |
| Bevacizumab | DB00112 | BTD00087 | BIOD00087 |
| C1 Esterase Inhibitor (Recombinant) | DB09228 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
