HCSGD entry for TNS1
1. General information
| Official gene symbol | TNS1 |
|---|---|
| Entrez ID | 7145 |
| Gene full name | tensin 1 |
| Other gene symbols | MST091 MST122 MST127 MSTP122 MSTP127 MXRA6 TNS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0007044 | Cell-substrate junction assembly | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010761 | Fibroblast migration | IEA | biological_process |
| GO:0030055 | Cell-substrate junction | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7105508985 | 0.0130963413 | 0.9999902473 | 0.2254995422 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0805695487 |
| GSE13712_SHEAR | Down | -0.9507028728 |
| GSE13712_STATIC | Down | -0.8586919827 |
| GSE19018 | Down | -0.5333335963 |
| GSE19899_A1 | Down | -0.3529721761 |
| GSE19899_A2 | Down | -0.7392026796 |
| PubMed_21979375_A1 | Down | -2.2444612069 |
| PubMed_21979375_A2 | Down | -0.2790173306 |
| GSE35957 | Up | 0.2392789784 |
| GSE36640 | Up | 0.1726262549 |
| GSE54402 | Up | 0.0383064964 |
| GSE9593 | Down | -0.0272952873 |
| GSE43922 | Down | -0.3857492311 |
| GSE24585 | Up | 0.2467814338 |
| GSE37065 | Up | 0.1748470913 |
| GSE28863_A1 | Up | 0.6411872666 |
| GSE28863_A2 | Up | 0.4246076669 |
| GSE28863_A3 | Down | -0.1117410282 |
| GSE28863_A4 | Down | -0.0281842609 |
| GSE48662 | Up | 0.2639448109 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019227 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027785 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26655726 | The phosphatase and tensin homolog gene PTEN is one of the most frequently mutated tumor suppressor genes in human cancer |
| 26511486 | Given that human prostate cancer arises from precancerous lesions such as high-grade prostatic intraepithelial neoplasia (HG-PIN), which frequently have lost phosphatase and tensin homolog (PTEN) tumor suppressor permitting phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (AKT) oncogenic signaling, we tested the efficacy of MSeA to inhibit HG-PIN progression in Pten prostate-specific knockout (KO) mice and assessed the mechanistic involvement of p53-mediated cellular senescence and of the androgen receptor (AR) |
| 24782600 | Activation of egr-1, in turn, upregulates the dual specificity phosphatase, phosphatase and tensin homologue deleted on chromosome ten (PTEN) resulting in activation of pro-apoptotic caspase-3 and caspase-9 and reduced expression of the anti-apoptosis protein, survivin |
| 24270409 | Although such 'escape' from senescence is not sufficient to promote thyroid tumorigenesis in adult mice up to 5 months, the onset of Phosphatase and tensin homolog (Pten)-induced tumor formation is accelerated when Spry1 is concomitantly eliminated |
| 20197621 | We previously demonstrated in a mouse model of prostate cancer that inactivation of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) elicits a senescence response that opposes tumorigenesis |
| 18765664 | S1P-induced Akt and ERK1/2 activation were comparable between ECs of different in vitro ages; however, PTEN (phosphatase and tensin homolog deleted on chromosome 10) activity was significantly elevated and Rac activation was inhibited in senescent ECs |
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