HCSGD entry for TNNT2
1. General information
| Official gene symbol | TNNT2 |
|---|---|
| Entrez ID | 7139 |
| Gene full name | troponin T type 2 (cardiac) |
| Other gene symbols | CMH2 CMPD2 LVNC6 RCM3 TnTC cTnT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005523 | Tropomyosin binding | IDA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005861 | Troponin complex | IDA IEA | cellular_component |
| GO:0005865 | Striated muscle thin filament | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006937 | Regulation of muscle contraction | IEA | biological_process |
| GO:0008016 | Regulation of heart contraction | IMP | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0030017 | Sarcomere | TAS | cellular_component |
| GO:0030049 | Muscle filament sliding | IDA TAS | biological_process |
| GO:0030172 | Troponin C binding | IPI | molecular_function |
| GO:0031013 | Troponin I binding | IPI | molecular_function |
| GO:0032780 | Negative regulation of ATPase activity | IDA | biological_process |
| GO:0032781 | Positive regulation of ATPase activity | IDA | biological_process |
| GO:0045214 | Sarcomere organization | IEA | biological_process |
| GO:0051592 | Response to calcium ion | IDA IMP | biological_process |
| GO:0055009 | Atrial cardiac muscle tissue morphogenesis | IEA | biological_process |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7626279739 | 0.2396220698 | 0.9999902473 | 0.9426233000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1082544242 |
| GSE13712_SHEAR | Down | -0.1263510358 |
| GSE13712_STATIC | Up | 0.0923170708 |
| GSE19018 | Down | -0.0434620313 |
| GSE19899_A1 | Up | 0.1591000293 |
| GSE19899_A2 | Up | 0.1922614372 |
| PubMed_21979375_A1 | Down | -0.3566931360 |
| PubMed_21979375_A2 | Down | -0.0226679880 |
| GSE35957 | Up | 0.2501768627 |
| GSE36640 | Down | -0.1462266474 |
| GSE54402 | Down | -0.1968631177 |
| GSE9593 | Up | 0.0721445016 |
| GSE43922 | Up | 0.1356248642 |
| GSE24585 | Down | -0.4268741451 |
| GSE37065 | Down | -0.1715805164 |
| GSE28863_A1 | Down | -0.1654372134 |
| GSE28863_A2 | Down | -0.1310210495 |
| GSE28863_A3 | Up | 0.3074753705 |
| GSE28863_A4 | Up | 0.1600060758 |
| GSE48662 | Down | -1.1552628124 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018337 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
