HCSGD entry for TNNI3
1. General information
| Official gene symbol | TNNI3 |
|---|---|
| Entrez ID | 7137 |
| Gene full name | troponin I type 3 (cardiac) |
| Other gene symbols | CMD1FF CMD2A CMH7 RCM1 TNNC1 cTnI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001570 | Vasculogenesis | ISS | biological_process |
| GO:0001980 | Regulation of systemic arterial blood pressure by ischemic conditions | ISS | biological_process |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005861 | Troponin complex | IDA IEA | cellular_component |
| GO:0006874 | Cellular calcium ion homeostasis | ISS | biological_process |
| GO:0006940 | Regulation of smooth muscle contraction | IEA | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0019855 | Calcium channel inhibitor activity | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030017 | Sarcomere | TAS | cellular_component |
| GO:0030049 | Muscle filament sliding | TAS | biological_process |
| GO:0030172 | Troponin C binding | IPI | molecular_function |
| GO:0031014 | Troponin T binding | IPI | molecular_function |
| GO:0032780 | Negative regulation of ATPase activity | IDA IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048306 | Calcium-dependent protein binding | IPI | molecular_function |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
| GO:0060047 | Heart contraction | IMP | biological_process |
| GO:0060048 | Cardiac muscle contraction | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6267576536 | 0.5278417461 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2346039732 |
| GSE13712_SHEAR | Up | 0.1096925585 |
| GSE13712_STATIC | Down | -0.0512228262 |
| GSE19018 | Up | 0.2395881248 |
| GSE19899_A1 | Up | 0.0146065486 |
| GSE19899_A2 | Down | -0.1851903820 |
| PubMed_21979375_A1 | Up | 0.1115654610 |
| PubMed_21979375_A2 | Down | -0.1600225446 |
| GSE35957 | Up | 0.1718439906 |
| GSE36640 | Up | 0.1336507484 |
| GSE54402 | Down | -0.0189880620 |
| GSE9593 | Up | 0.0768416074 |
| GSE43922 | Up | 0.0125365483 |
| GSE24585 | Up | 0.2205907713 |
| GSE37065 | Down | -0.0115398752 |
| GSE28863_A1 | Down | -0.1297968640 |
| GSE28863_A2 | Down | -0.0267139224 |
| GSE28863_A3 | Up | 0.4323490364 |
| GSE28863_A4 | Up | 0.0020680516 |
| GSE48662 | Down | -0.4504686135 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide | DB04513 | EXPT03246 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT020004 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
