HCSGD entry for TNFRSF1A

1. General information

Official gene symbolTNFRSF1A
Entrez ID7132
Gene full nametumor necrosis factor receptor superfamily, member 1A
Other gene symbolsCD120a FPF MS5 TBP1 TNF-R TNF-R-I TNF-R55 TNFAR TNFR1 TNFR1-d2 TNFR55 TNFR60 p55 p55-R p60
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIDAcellular_component
GO:0001666Response to hypoxiaIEAbiological_process
GO:0002020Protease bindingIEAmolecular_function
GO:0005031Tumor necrosis factor-activated receptor activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006693Prostaglandin metabolic processIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006954Inflammatory responseIEA ISSbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsTASbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayISSbiological_process
GO:0030424AxonIEAcellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0033013Tetrapyrrole metabolic processIEAbiological_process
GO:0033160Positive regulation of protein import into nucleus, translocationIEAbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIMPbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043120Tumor necrosis factor bindingIEAmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0043279Response to alkaloidIEAbiological_process
GO:0045121Membrane raftIDA IEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA IMP ISSbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0050729Positive regulation of inflammatory responseIEA ISSbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071392Cellular response to estradiol stimulusIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30526130850.45625493330.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1725759053
GSE13712_SHEARUp0.1435147587
GSE13712_STATICUp0.2301429486
GSE19018Down-0.1944408575
GSE19899_A1Down-0.1897327704
GSE19899_A2Up0.3578173481
PubMed_21979375_A1Down-0.0495495592
PubMed_21979375_A2Up0.5943764869
GSE35957Down-0.2743061404
GSE36640Up0.5155026805
GSE54402Down-0.2228136633
GSE9593Down-0.0583232144
GSE43922Down-0.0473944424
GSE24585Down-0.2574361254
GSE37065Down-0.1962592485
GSE28863_A1Up0.5980832114
GSE28863_A2Up0.2665318737
GSE28863_A3Down-0.3011332965
GSE28863_A4Up0.1010297202
GSE48662Up0.4323198481

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL150870CHEMBL33788P19438
CHEMBL517647CHEMBL33788P19438
CHEMBL151328CHEMBL33788P19438
CHEMBL357092CHEMBL33788P19438
CHEMBL481968CHEMBL33788P19438
CHEMBL151107CHEMBL33788P19438
CHEMBL423208CHEMBL33788P19438
CHEMBL149465CHEMBL33788P19438
CHEMBL151946CHEMBL33788P19438
CHEMBL155504CHEMBL33788P19438
CHEMBL150651CHEMBL33788P19438
CHEMBL481969CHEMBL33788P19438
CHEMBL359348CHEMBL33788P19438
CHEMBL151203CHEMBL33788P19438
CHEMBL150992CHEMBL33788P19438
CHEMBL356012CHEMBL33788P19438
CHEMBL355913CHEMBL33788P19438
CHEMBL356830CHEMBL33788P19438
CHEMBL356815CHEMBL33788P19438
CHEMBL347715CHEMBL33788P19438
CHEMBL147036CHEMBL33788P19438
CHEMBL151153CHEMBL33788P19438
CHEMBL150292CHEMBL33788P19438
CHEMBL465465CHEMBL33788P19438
CHEMBL150886CHEMBL33788P19438
CHEMBL357999CHEMBL33788P19438
CHEMBL151686CHEMBL33788P19438
CHEMBL149958CHEMBL33788P19438
CHEMBL151752CHEMBL33788P19438
CHEMBL345771CHEMBL33788P19438
CHEMBL151578CHEMBL33788P19438
CHEMBL357328CHEMBL33788P19438
CHEMBL150675CHEMBL33788P19438
CHEMBL345500CHEMBL33788P19438
CHEMBL146955CHEMBL33788P19438
CHEMBL345772CHEMBL33788P19438
CHEMBL359346CHEMBL33788P19438
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  • Drugs

Name

Drug

Accession number

6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-OneDB03507 EXPT00294

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7e-5pMIMAT0000066MIRT051697CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25077560Here we show in different models of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (ADAM17) is activated and releases the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor receptor I (TNFRI) from the surface of senescent cells by ectodomain shedding
18180277Clinical and functional characterisation of a novel TNFRSF1A c
18180277OBJECTIVES: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site
18180277METHODS: Patients with symptoms suggestive of tumour necrosis factor receptor-associated periodic syndrome (TRAPS) and 22 healthy controls (HC) were screened for mutations in the TNFRSF1A gene
18180277Soluble TNFRSF1A and inflammatory cytokines were measured by ELISAs
18180277TNFRSF1A shedding was examined by stimulation of peripheral blood mononuclear cells (PBMCs) with phorbol 12-myristate 13-acetate followed by flow cytometric analysis (FACS)
18180277RESULTS: TNFRSF1A sequencing disclosed a novel V173D/p
18180277Serum TNFRSF1A levels did not differ between TRAPS patients and HC, while TNFRSF1A cleavage from monocytes was significantly reduced in V173D and R92Q patients
18180277CONCLUSIONS: The TNFRSF1A V173D cleavage site mutation may be associated with an increased risk for cardiovascular complications and shows a strong response to etanercept
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