HCSGD entry for TLR5

1. General information

Official gene symbolTLR5
Entrez ID7100
Gene full nametoll-like receptor 5
Other gene symbolsSLEB1 TIL3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0005149Interleukin-1 receptor bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0034123Positive regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19180907640.73443702750.84993378791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0134335345
GSE13712_SHEARUp0.0573598337
GSE13712_STATICDown-0.0131258733
GSE19018Down-0.0395020592
GSE19899_A1Up0.1177881285
GSE19899_A2Down-0.0661817921
PubMed_21979375_A1Up0.1610790144
PubMed_21979375_A2Up0.1270508536
GSE35957Up0.1587177236
GSE36640Up0.1148501671
GSE54402Down-0.2437912804
GSE9593Up0.0191382520
GSE43922Down-0.0238017910
GSE24585Up0.8480965548
GSE37065Up0.1605762700
GSE28863_A1Up0.3327646733
GSE28863_A2Up0.2500340444
GSE28863_A3Down-0.0520611876
GSE28863_A4Down-0.3128507848
GSE48662Up0.0453112151

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.