HCSGD entry for TLR3

1. General information

Official gene symbolTLR3
Entrez ID7098
Gene full nametoll-like receptor 3
Other gene symbolsCD283 IIAE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayIEA TASbiological_process
GO:0003725Double-stranded RNA bindingIDA IEA NASmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006972Hyperosmotic responseNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0009597Detection of virusNASbiological_process
GO:0009986Cell surfaceIDA IEAcellular_component
GO:0010008Endosome membraneTAScellular_component
GO:0016020MembraneNAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0032722Positive regulation of chemokine productionIDA IEAbiological_process
GO:0032728Positive regulation of interferon-beta productionIEA ISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEA ISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDA IEAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEA ISSbiological_process
GO:0034123Positive regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayIEA TASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034346Positive regulation of type III interferon productionIEAbiological_process
GO:0035458Cellular response to interferon-betaIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035690Cellular response to drugIEAbiological_process
GO:0036020Endolysosome membraneTAScellular_component
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042742Defense response to bacteriumTASbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043330Response to exogenous dsRNAIDA IEAbiological_process
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045080Positive regulation of chemokine biosynthetic processIEAbiological_process
GO:0045087Innate immune responseIEA TASbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDA IMPbiological_process
GO:0045671Negative regulation of osteoclast differentiationNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIC IEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0051607Defense response to virusIEA TASbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:0071360Cellular response to exogenous dsRNAIEAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:0097527Necroptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00844552640.45930822540.23701782701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0105996960
GSE13712_SHEARUp1.5782603407
GSE13712_STATICUp1.7371388546
GSE19018Down-0.0997017917
GSE19899_A1Up0.1202664250
GSE19899_A2Down-0.5764143691
PubMed_21979375_A1Down-0.1251953028
PubMed_21979375_A2Down-0.1977308980
GSE35957Down-0.9794846676
GSE36640Up1.1364051020
GSE54402Down-0.4273473626
GSE9593Up1.1299756725
GSE43922Down-0.1835408103
GSE24585Up1.2269819034
GSE37065Up0.9567216966
GSE28863_A1Up0.4963123735
GSE28863_A2Up0.4285373224
GSE28863_A3Up0.1067969247
GSE28863_A4Down-0.0790333243
GSE48662Down-0.0212467604

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022528MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24165198SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes
24165198Of interest is the novel finding that SORBS2 and TLR3 can induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines
24165198CONCLUSIONS: The relevance of the genes SORBS2 and TLR3 in the process of cellular senescence warrants further investigation
22843797Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency
22843797Using the RNA mimetic polyinosinic-polycytidylic acid [poly(I:C)] to engage MSC Toll-like receptor 3 (TLR3), we found that poly(I:C), signaling through multiple mitogen-activated protein kinase pathways, induced therapeutically relevant trophic factors such as interleukin-6-type cytokines, stromal-derived factor 1, hepatocyte growth factor, and vascular endothelial growth factor while slightly inhibiting the proliferation and migration potentials of MSC
22843797These functional, histological, and molecular characterizations thus establish the utility of TLR3 engagement for enabling the low-dose MSC therapy that may be translated to more efficacious clinical applications
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