HCSGD entry for TLR2

1. General information

Official gene symbolTLR2
Entrez ID7097
Gene full nametoll-like receptor 2
Other gene symbolsCD282 TIL4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001875Lipopolysaccharide receptor activityTASmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002238Response to molecule of fungal originIEAbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002687Positive regulation of leukocyte migrationIEAbiological_process
GO:0002752Cell surface pattern recognition receptor signaling pathwayIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004872Receptor activityIDAmolecular_function
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006691Leukotriene metabolic processIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008329Signaling pattern recognition receptor activityIDAmolecular_function
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0030177Positive regulation of Wnt signaling pathwayIMPbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayTASbiological_process
GO:0032289Central nervous system myelin formationIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032695Negative regulation of interleukin-12 productionIEAbiological_process
GO:0032700Negative regulation of interleukin-17 productionIEAbiological_process
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032728Positive regulation of interferon-beta productionISSbiological_process
GO:0032733Positive regulation of interleukin-10 productionIEAbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032741Positive regulation of interleukin-18 productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0034123Positive regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complexIDAcellular_component
GO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complexIEAcellular_component
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042495Detection of triacyl bacterial lipopeptideIDAbiological_process
GO:0042496Detection of diacyl bacterial lipopeptideIDAbiological_process
GO:0042497Triacyl lipopeptide bindingIDAmolecular_function
GO:0042498Diacyl lipopeptide bindingIEAmolecular_function
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIEAbiological_process
GO:0042834Peptidoglycan bindingIDAmolecular_function
GO:0042892Chloramphenicol transportIEAbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0044297Cell bodyIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046209Nitric oxide metabolic processIEAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0050715Positive regulation of cytokine secretionIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0050830Defense response to Gram-positive bacteriumIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processISSbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0052063Induction by symbiont of defense-related host nitric oxide productionIEAbiological_process
GO:0060907Positive regulation of macrophage cytokine productionIEAbiological_process
GO:0070542Response to fatty acidIEAbiological_process
GO:0070891Lipoteichoic acid bindingIEAmolecular_function
GO:0071221Cellular response to bacterial lipopeptideTASbiological_process
GO:0071223Cellular response to lipoteichoic acidIDAbiological_process
GO:0071224Cellular response to peptidoglycanIEAbiological_process
GO:0071726Cellular response to diacyl bacterial lipopeptideIDAbiological_process
GO:0071727Cellular response to triacyl bacterial lipopeptideIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00670634090.94168243990.21511887941.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0542897919
GSE13712_SHEARUp0.0198190912
GSE13712_STATICUp0.0541655327
GSE19018Up0.1013965698
GSE19899_A1Up0.3306421537
GSE19899_A2Up0.6688913996
PubMed_21979375_A1Up2.1086331327
PubMed_21979375_A2Up0.9818853340
GSE35957Down-0.2291129261
GSE36640Down-0.0674846986
GSE54402Up4.3807211720
GSE9593Down-0.2252570652
GSE43922Up0.0104176524
GSE24585Up0.2364020440
GSE37065Up0.3915511705
GSE28863_A1Up0.3796921947
GSE28863_A2Up0.4770275260
GSE28863_A3Up0.0443089977
GSE28863_A4Up0.2313855143
GSE48662Down-0.0179762166

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OspA lipoproteinDB00045 BTD00054 | BIOD00054
S-(Dimethylarsenic)CysteineDB03963 EXPT00832
SCV-07DB05475 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT000449qRT-PCR//flow//Luciferase reporter assay//Western blot//qRT-PCR;OtherFunctional MTI20375304
hsa-miR-105-5pMIMAT0000102MIRT001127Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19509287
hsa-miR-19a-3pMIMAT0000073MIRT006646Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
hsa-miR-19b-3pMIMAT0000074MIRT006647Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
hsa-miR-335-5pMIMAT0000765MIRT019178MicroarrayFunctional MTI (Weak)18185580
hsa-miR-106b-5pMIMAT0000680MIRT020445MicroarrayFunctional MTI (Weak)17242205
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-105-5pMIMAT00001021hsa-miR-105{Western blot}{downregulation}19509287
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24917789In contrast, 16 DIV (aged) microglia evidenced ramified morphology and increased matrix metalloproteinase (MMP)-2 activation, as well as reduced MMP-9, glutamate release and nuclear factor kappa-B activation, in parallel with decreased expression of Toll-like receptor (TLR)-2 and TLR-4, capacity to migrate and phagocytose
22859216Targeting of Toll-like receptor (TLR) 2 attenuates tumor metastases; we hypothesized that blocking TLR2 might also play a crucial role in reducing hepatocarcinogenesis
Entries Per Page
Displaying Page of