HCSGD entry for TLR1

1. General information

Official gene symbolTLR1
Entrez ID7096
Gene full nametoll-like receptor 1
Other gene symbolsCD281 TIL TIL. LPRS5 rsc786
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityIEA NASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006952Defense responseIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0016020MembraneNAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030670Phagocytic vesicle membraneIEAcellular_component
GO:0034150Toll-like receptor 6 signaling pathwayIEAbiological_process
GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complexIDAcellular_component
GO:0042088T-helper 1 type immune responseIEAbiological_process
GO:0042116Macrophage activationNASbiological_process
GO:0042495Detection of triacyl bacterial lipopeptideIDAbiological_process
GO:0042496Detection of diacyl bacterial lipopeptideIEAbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIEA ISSbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045410Positive regulation of interleukin-6 biosynthetic processIEA ISSbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0071727Cellular response to triacyl bacterial lipopeptideIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17043722120.80241691050.81254810721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2070795468
GSE13712_SHEARDown-0.5208989125
GSE13712_STATICUp0.6650958043
GSE19018Up0.1903410694
GSE19899_A1Up0.0421957598
GSE19899_A2Down-0.1854173230
PubMed_21979375_A1Up0.0521758112
PubMed_21979375_A2Down-0.1070072310
GSE35957Up0.1045958647
GSE36640Up0.6065642654
GSE54402Up0.0559612282
GSE9593Down-0.1111013793
GSE43922Up0.0197345986
GSE24585Up0.2953516812
GSE37065Up0.4222545206
GSE28863_A1Up0.0504786029
GSE28863_A2Up0.3467814625
GSE28863_A3Down-0.0281246856
GSE28863_A4Down-0.0967826268
GSE48662Down-0.1136788313

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018819MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030134MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.