HCSGD entry for TLN1
1. General information
| Official gene symbol | TLN1 |
|---|---|
| Entrez ID | 7094 |
| Gene full name | talin 1 |
| Other gene symbols | ILWEQ TLN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA ISS | cellular_component |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005158 | Insulin receptor binding | IEA | molecular_function |
| GO:0005178 | Integrin binding | IPI | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IC | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA ISS NAS | cellular_component |
| GO:0006928 | Cellular component movement | NAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007016 | Cytoskeletal anchoring at plasma membrane | IEA NAS | biological_process |
| GO:0007043 | Cell-cell junction assembly | TAS | biological_process |
| GO:0007044 | Cell-substrate junction assembly | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0017166 | Vinculin binding | IPI | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030274 | LIM domain binding | IPI | molecular_function |
| GO:0030866 | Cortical actin cytoskeleton organization | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0375911592 | 0.6994600471 | 0.4378039381 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3080176247 |
| GSE13712_SHEAR | Up | 0.1774162383 |
| GSE13712_STATIC | Up | 0.1409762338 |
| GSE19018 | Up | 0.2182415284 |
| GSE19899_A1 | Down | -0.0984073095 |
| GSE19899_A2 | Up | 0.3996691455 |
| PubMed_21979375_A1 | Up | 0.0012395943 |
| PubMed_21979375_A2 | Up | 0.2494650945 |
| GSE35957 | Up | 0.0232061624 |
| GSE36640 | Up | 0.1410061200 |
| GSE54402 | Up | 0.0384708426 |
| GSE9593 | Up | 0.0285401342 |
| GSE43922 | Down | -0.1944674245 |
| GSE24585 | Up | 0.1258835494 |
| GSE37065 | Down | -0.4242744744 |
| GSE28863_A1 | Up | 1.5781450752 |
| GSE28863_A2 | Up | 1.1906653592 |
| GSE28863_A3 | Up | 0.3747439325 |
| GSE28863_A4 | Down | -0.0789433031 |
| GSE48662 | Up | 0.1561127819 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002693 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002693 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-760 | MIMAT0004957 | MIRT036748 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040638 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042279 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045248 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046642 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049677 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050319 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052208 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
