HCSGD entry for TLE3
1. General information
| Official gene symbol | TLE3 |
|---|---|
| Entrez ID | 7090 |
| Gene full name | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) |
| Other gene symbols | ESG ESG3 GRG3 HsT18976 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0387245355 | 0.4604891645 | 0.4442262402 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1342548291 |
| GSE13712_SHEAR | Down | -0.4499015322 |
| GSE13712_STATIC | Down | -0.1027417635 |
| GSE19018 | Down | -0.4153749131 |
| GSE19899_A1 | Up | 0.2034661839 |
| GSE19899_A2 | Up | 0.7924266498 |
| PubMed_21979375_A1 | Up | 1.2183718749 |
| PubMed_21979375_A2 | Up | 1.7757521145 |
| GSE35957 | Down | -1.0892621021 |
| GSE36640 | Down | -0.8038055482 |
| GSE54402 | Up | 0.5717382069 |
| GSE9593 | Down | -0.4696753462 |
| GSE43922 | Up | 0.7665390210 |
| GSE24585 | Down | -0.1280795508 |
| GSE37065 | Up | 0.0613645036 |
| GSE28863_A1 | Up | 0.1783798011 |
| GSE28863_A2 | Up | 0.1626426666 |
| GSE28863_A3 | Up | 0.4085977683 |
| GSE28863_A4 | Up | 0.0672568649 |
| GSE48662 | Down | -0.0951570276 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025609 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038491 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040320 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041003 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042697 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046791 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047341 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048880 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049557 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050664 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052775 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
