HCSGD entry for TLE2

1. General information

Official gene symbolTLE2
Entrez ID7089
Gene full nametransducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Other gene symbolsESG ESG2 GRG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.76549300940.07029680100.99999024730.5007484037

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0942244215
GSE13712_SHEARDown-1.8997739762
GSE13712_STATICDown-1.3796611685
GSE19018Up0.1604837166
GSE19899_A1Up0.1047173485
GSE19899_A2Up0.0872816123
PubMed_21979375_A1Up0.0859873625
PubMed_21979375_A2Down-0.0015011393
GSE35957Down-0.3370763059
GSE36640Down-0.0546926391
GSE54402Down-0.1851039678
GSE9593Down-0.8491180013
GSE43922Up0.1211152220
GSE24585Up0.0610196872
GSE37065Up0.0029345324
GSE28863_A1Down-0.1333351603
GSE28863_A2Down-0.2291135619
GSE28863_A3Up0.4458899141
GSE28863_A4Up0.0409443886
GSE48662Up0.1107765121

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.